PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
epidermal growth factor receptorENSG00000146648EGFRchr7:55019021-55256620:+Tclin20800
fms related receptor tyrosine kinase 3ENSG00000122025FLT3chr13:28003274-28100592:-Tclin1525.44
cyclin E1ENSG00000105173CCNE1chr19:29811898-29824308:+Tchem298.54
BCL2 apoptosis regulatorENSG00000171791BCL2chr18:63123346-63320128:-Tclin12509.2
DNA topoisomerase II alphaENSG00000131747TOP2Achr17:40388516-40417950:-Tclin609.249
MET proto-oncogene, receptor tyrosine kinaseENSG00000105976METchr7:116672390-116798386:+Tclin1522.99
fibroblast growth factor receptor 2ENSG00000066468FGFR2chr10:121478334-121598458:-Tclin1106.77
RAD51 recombinaseENSG00000051180RAD51chr15:40694774-40732339:+Tchem1974.97
BUB1 mitotic checkpoint serine/threonine kinase BENSG00000156970BUB1Bchr15:40161023-40221136:+Tbio248.837
erb-b2 receptor tyrosine kinase 2ENSG00000141736ERBB2chr17:39687914-39730426:+Tclin16163
baculoviral IAP repeat containing 5ENSG00000089685BIRC5chr17:78214186-78225636:+Tchem801.619
checkpoint kinase 1ENSG00000149554CHEK1chr11:125625136-125676255:+Tchem805.375
cyclin dependent kinase 1ENSG00000170312CDK1chr10:60778331-60794852:+Tchem1804.43
fibroblast growth factor receptor 3ENSG00000068078FGFR3chr4:1793307-1808872:+Tclin1032.93
Janus kinase 2ENSG00000096968JAK2chr9:4985033-5128183:+Tclin2952.78
cyclin dependent kinase 6ENSG00000105810CDK6chr7:92604921-92836594:-Tclin374.932
polo like kinase 1ENSG00000166851PLK1chr16:23677656-23690367:+Tchem931.921
aurora kinase AENSG00000087586AURKAchr20:56369389-56392337:-Tchem959.652
TTK protein kinaseENSG00000112742TTKchr6:80003887-80042527:+Tchem132.457
estrogen receptor 1ENSG00000091831ESR1chr6:151656691-152129619:+Tclin11099.5

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