The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]
Overall distribution
Tissue specific distribution
Expression restricted in 9 cancer type(s)
Cancer specific in breast cancer subtype (Basal; TNBC)
Overall distribution
Tissue specific distribution
Gscore (Amp):
0.00
Gscore (Del):
1.02 (Driver)
Recurrently deleted in 5 cancer type(s)
Overall distribution
Tissue specific distribution
Mscore:
0.00
Overall
Tissue specific
Total fusion occurrence:
2
Fusions detected in 2 cancer type(s)
Overall
Tissue specific
CRISPR: COMMON ESSENTIAL; ST
Functional class:
Kinase (protein kinase)
JensenLab PubMed score:
1089.60 (Percentile rank: 95.74%)
PubTator score:
805.37 (Percentile rank: 95.70%)
Target development/druggability level:
TchemThese targets have activities in ChEMBL or DrugCentral that satisfy the activity thresholds detailed below.
Tractability (small molecule):
Clinical PrecedenceTargets with drugs in phase II or above; Pre-clinical targets
