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      Official symbol:  TTK
      Full name:  TTK protein kinase
      Location:  6q14.1
      Also known as:  MPS1L1, MPH1, CT96, MPS1
      Entrez ID:  7272
      Ensembl ID:  ENSG00000112742
      Summary:  This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]


  Overall distribution
  Tissue specific distribution
Expression restricted in 14 cancer type(s)
Cancer specific in breast cancer subtype (Basal; Her2; LumB; T)

  Overall distribution
  Tissue specific distribution
Gscore (Amp):  0.00  
Gscore (Del):  0.16  
Recurrently deleted in 1 cancer type(s)

  Overall distribution
  Tissue specific distribution
Mscore:  0.17  (Driver)
Recurrently mutated in 2 cancer type(s)

  Tissue specific
Total fusion occurrence:  2  
Fusions detected in 2 cancer type(s)

  Tissue specific

      Functional class:  Kinase (protein kinase)
      JensenLab PubMed score:  219.09  (Percentile rank: 82.72%)
      PubTator score:  132.46  (Percentile rank: 81.39%)
      Target development/druggability level:  TchemThese targets have activities in ChEMBL or DrugCentral that satisfy the activity thresholds detailed below.
      Tractability (small molecule):  Clinical PrecedenceTargets with drugs in phase II or above; Pre-clinical targets
      Tractability (antibody):  


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