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TTK  
    


    
      Official symbol:  TTK
      Full name:  TTK protein kinase
      Location:  6q14.1
      Also known as:  MPS1L1, MPH1, CT96, MPS1
      Entrez ID:  7272
      Ensembl ID:  ENSG00000112742
      Summary:  This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]

    

    
  Overall distribution
    
  Tissue specific distribution
    
 
  
 
Expression restricted in 14 cancer type(s)
Cancer specific in breast cancer subtype (Basal; Her2; LumB; T)
   

    
  Overall distribution
    
  Tissue specific distribution
    
 
Gscore (Amp):  0.00  
Gscore (Del):  0.16  
 
Recurrently deleted in 1 cancer type(s)
   

    
  Overall distribution
    
  Tissue specific distribution
    
 
Mscore:  0.17  (Driver)
 
Recurrently mutated in 2 cancer type(s)
   

    
  Overall
    
  Tissue specific
    
 
Total fusion occurrence:  2  
 
Fusions detected in 2 cancer type(s)
 
 

    
  Overall
    
  Tissue specific
    
   CRISPR: COMMON ESSENTIAL 
 RNAi: COMMON ESSENTIAL 
   
   

    
      Functional class:  Kinase (protein kinase)
      JensenLab PubMed score:  219.09  (Percentile rank: 82.72%)
      PubTator score:  132.46  (Percentile rank: 81.39%)
      Target development/druggability level:  TchemThese targets have activities in ChEMBL or DrugCentral that satisfy the activity thresholds detailed below.
      Tractability (small molecule):  Clinical PrecedenceTargets with drugs in phase II or above; Pre-clinical targets
      Tractability (antibody):  

    







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