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      Official symbol:  BUB1B
      Full name:  BUB1 mitotic checkpoint serine/threonine kinase B
      Location:  15q15.1
      Also known as:  SSK1, BUBR1, Bub1A, MAD3L
      Entrez ID:  701
      Ensembl ID:  ENSG00000156970
      Summary:  This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq, Jul 2008]


  Overall distribution
  Tissue specific distribution
Expression restricted in 7 cancer type(s)

  Overall distribution
  Tissue specific distribution
Gscore (Amp):  0.00  
Gscore (Del):  0.69  (Driver)
Recurrently deleted in 2 cancer type(s)

  Overall distribution
  Tissue specific distribution
Mscore:  0.00  

  Tissue specific
Total fusion occurrence:  8  
Fusions detected in 4 cancer type(s)

  Tissue specific

      Functional class:  Kinase (protein kinase)
      JensenLab PubMed score:  309.15  (Percentile rank: 86.59%)
      PubTator score:  248.84  (Percentile rank: 88.08%)
      Target development/druggability level:  TbioThese targets do not have known drug or small molecule activities that satisfy the activity thresholds detailed below AND satisfy one or more of the following criteria: 1) target is above the cutoff criteria for Tdark; 2) target is annotated with a Gene Ontology Molecular Function or Biological Process leaf term(s) with an Experimental Evidence code.
      Tractability (small molecule):  Predicted TractableTargets with a predicted Ro5 druggable domain (druggable genome); Targets with a drugEBIlity score equal or greater than 0
      Tractability (antibody):  


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