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      Official symbol:  BCL2
      Full name:  BCL2, apoptosis regulator
      Location:  18q21.33
      Also known as:  Bcl-2, PPP1R50
      Entrez ID:  596
      Ensembl ID:  ENSG00000171791
      Summary:  This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]


  Overall distribution
  Tissue specific distribution

  Overall distribution
  Tissue specific distribution
Gscore (Amp):  0.20  
Gscore (Del):  0.53  
Recurrently amplified in 1 cancer type(s)
Recurrently deleted in 4 cancer type(s)

  Overall distribution
  Tissue specific distribution
Mscore:  0.00  

  Tissue specific
Total fusion occurrence:  2  
Fusions detected in 2 cancer type(s)

  Tissue specific

      Functional class:  Not specified
      JensenLab PubMed score:  130.56  (Percentile rank: 76.25%)
      PubTator score:  12509.20  (Percentile rank: 99.87%)
      Target development/druggability level:  TclinThese targets have activities in DrugCentral (ie. approved drugs) with known mechanism of action.
      Tractability (small molecule):  Clinical PrecedenceTargets with drugs in phase II or above; Pre-clinical targets
      Tractability (antibody):  Predicted Tractable - Medium to low confidenceTargets with GO cell component terms plasma membrane or secreted with low or unknown confidence; Targets with predicted signal peptide and transmembrane domains; GO cell component - medium confidence; Human Protein Atlas - high confidence


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