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      Official symbol:  RAD51
      Full name:  RAD51 recombinase
      Location:  15q15.1
      Also known as:  FANCR, HsRad51, RAD51A, BRCC5, HsT16930, RECA
      Entrez ID:  5888
      Ensembl ID:  ENSG00000051180
      Summary:  The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]


  Overall distribution
  Tissue specific distribution
Expression restricted in 9 cancer type(s)
Cancer specific in breast cancer subtype (Basal; Her2; TNBC)

  Overall distribution
  Tissue specific distribution
Gscore (Amp):  0.00  
Gscore (Del):  0.28  
Recurrently deleted in 2 cancer type(s)

  Overall distribution
  Tissue specific distribution
Mscore:  0.00  

  Tissue specific
Total fusion occurrence:  2  
Fusions detected in 2 cancer type(s)

  Tissue specific

      Functional class:  Not specified
      JensenLab PubMed score:  6589.98  (Percentile rank: 99.47%)
      PubTator score:  1974.97  (Percentile rank: 98.28%)
      Target development/druggability level:  TchemThese targets have activities in ChEMBL or DrugCentral that satisfy the activity thresholds detailed below.
      Tractability (small molecule):  Discovery PrecedenceTargets with ligands; Targets with crystal structures with ligands
      Tractability (antibody):  


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