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      Official symbol:  BIRC5
      Full name:  baculoviral IAP repeat containing 5
      Location:  17q25.3
      Also known as:  EPR-1, survivin, API4
      Entrez ID:  332
      Ensembl ID:  ENSG00000089685
      Summary:  This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011]


  Overall distribution
  Tissue specific distribution
Expression restricted in 15 cancer type(s)
Cancer specific in breast cancer subtype (Basal; Her2; LumB; T)

  Overall distribution
  Tissue specific distribution
Gscore (Amp):  0.88  (Driver)
Gscore (Del):  0.00  
Recurrently amplified in 4 cancer type(s)

  Overall distribution
  Tissue specific distribution
Mscore:  0.00  

  Tissue specific
Total fusion occurrence:  1  
Fusions detected in 1 cancer type(s)

  Tissue specific

      Functional class:  Not specified
      JensenLab PubMed score:  132.54  (Percentile rank: 76.47%)
      PubTator score:  801.62  (Percentile rank: 95.68%)
      Target development/druggability level:  TchemThese targets have activities in ChEMBL or DrugCentral that satisfy the activity thresholds detailed below.
      Tractability (small molecule):  Discovery PrecedenceTargets with ligands; Targets with crystal structures with ligands
      Tractability (antibody):  


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