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      Official symbol:  CCNE1
      Full name:  cyclin E1
      Location:  19q12
      Also known as:  CCNE
      Entrez ID:  898
      Ensembl ID:  ENSG00000105173
      Summary:  The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. [provided by RefSeq, Apr 2016]


  Overall distribution
  Tissue specific distribution
Expression restricted in 4 cancer type(s)

  Overall distribution
  Tissue specific distribution
Gscore (Amp):  5.85  (Driver)
Gscore (Del):  0.00  
Recurrently amplified in 11 cancer type(s)

  Overall distribution
  Tissue specific distribution
Mscore:  0.00  

  Tissue specific
Total fusion occurrence:  NA  

  Tissue specific

      Functional class:  Not specified
      JensenLab PubMed score:  262.39  (Percentile rank: 84.70%)
      PubTator score:  298.54  (Percentile rank: 89.67%)
      Target development/druggability level:  TchemThese targets have activities in ChEMBL or DrugCentral that satisfy the activity thresholds detailed below.
      Tractability (small molecule):  Discovery PrecedenceTargets with ligands; Targets with crystal structures with ligands
      Tractability (antibody):  


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