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      Official symbol:  JAK2
      Full name:  Janus kinase 2
      Location:  9p24.1
      Also known as:  JTK10
      Entrez ID:  3717
      Ensembl ID:  ENSG00000096968
      Summary:  This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. [provided by RefSeq, Jul 2008]


  Overall distribution
  Tissue specific distribution

  Overall distribution
  Tissue specific distribution
Gscore (Amp):  0.59  
Gscore (Del):  0.31  
Recurrently amplified in 3 cancer type(s)
Recurrently deleted in 2 cancer type(s)

  Overall distribution
  Tissue specific distribution
Mscore:  0.05  
Recurrently mutated in 1 cancer type(s)

  Tissue specific
Total fusion occurrence:  13  (Driver)
Fusions detected in 7 cancer type(s)

  Tissue specific

      Functional class:  Kinase (protein kinase)
      JensenLab PubMed score:  3339.72  (Percentile rank: 98.79%)
      PubTator score:  2952.78  (Percentile rank: 98.95%)
      Target development/druggability level:  TclinThese targets have activities in DrugCentral (ie. approved drugs) with known mechanism of action.
      Tractability (small molecule):  Clinical PrecedenceTargets with drugs in phase II or above; Pre-clinical targets
      Tractability (antibody):  Predicted Tractable - High confidenceTargets located in the plasma membrane; Targets with GO cell component terms plasma membrane or secreted


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