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      Official symbol:  ESR1
      Full name:  estrogen receptor 1
      Location:  6q25.1-q25.2
      Also known as:  ESR, Era, ER-alpha, NR3A1
      Entrez ID:  2099
      Ensembl ID:  ENSG00000091831
      Summary:  This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014]


  Overall distribution
  Tissue specific distribution
Cancer specific in breast cancer subtype (LumB)

  Overall distribution
  Tissue specific distribution
Gscore (Amp):  0.00  
Gscore (Del):  0.00  

  Overall distribution
  Tissue specific distribution
Mscore:  0.05  
Recurrently mutated in 1 cancer type(s)

  Tissue specific
Total fusion occurrence:  30  (Driver)
Fusions detected in 5 cancer type(s)

  Tissue specific

      Functional class:  Nuclear hormone receptor
      JensenLab PubMed score:  8421.58  (Percentile rank: 99.60%)
      PubTator score:  11099.47  (Percentile rank: 99.83%)
      Target development/druggability level:  TclinThese targets have activities in DrugCentral (ie. approved drugs) with known mechanism of action.
      Tractability (small molecule):  Clinical PrecedenceTargets with drugs in phase II or above; Pre-clinical targets
      Tractability (antibody):  Predicted Tractable - High confidenceTargets located in the plasma membrane; Targets with GO cell component terms plasma membrane or secreted


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