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      Official symbol:  CDK1
      Full name:  cyclin dependent kinase 1
      Location:  10q21.2
      Also known as:  CDC2, CDC28A
      Entrez ID:  983
      Ensembl ID:  ENSG00000170312
      Summary:  The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]


  Overall distribution
  Tissue specific distribution
Expression restricted in 15 cancer type(s)
Cancer specific in breast cancer subtype (Basal; Her2; LumB; T)

  Overall distribution
  Tissue specific distribution
Gscore (Amp):  0.00  
Gscore (Del):  0.00  

  Overall distribution
  Tissue specific distribution
Mscore:  0.00  

  Tissue specific
Total fusion occurrence:  3  
Fusions detected in 3 cancer type(s)

  Tissue specific

      Functional class:  Kinase (protein kinase)
      JensenLab PubMed score:  1790.25  (Percentile rank: 97.59%)
      PubTator score:  1804.43  (Percentile rank: 98.06%)
      Target development/druggability level:  TchemThese targets have activities in ChEMBL or DrugCentral that satisfy the activity thresholds detailed below.
      Tractability (small molecule):  Clinical PrecedenceTargets with drugs in phase II or above; Pre-clinical targets
      Tractability (antibody):  


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