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      Official symbol:  PLK1
      Full name:  polo like kinase 1
      Location:  16p12.2
      Also known as:  PLK
      Entrez ID:  5347
      Ensembl ID:  ENSG00000166851
      Summary:  The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of this protein in cancer cells dramatically inhibited cell proliferation and induced apoptosis; hence, it is a target for cancer therapy. [provided by RefSeq, Sep 2015]


  Overall distribution
  Tissue specific distribution
Expression restricted in 10 cancer type(s)
Cancer specific in breast cancer subtype (Basal; TNBC)

  Overall distribution
  Tissue specific distribution
Gscore (Amp):  0.00  
Gscore (Del):  0.00  

  Overall distribution
  Tissue specific distribution
Mscore:  0.00  

  Tissue specific
Total fusion occurrence:  1  
Fusions detected in 1 cancer type(s)

  Tissue specific

      Functional class:  Kinase (protein kinase)
      JensenLab PubMed score:  1271.15  (Percentile rank: 96.50%)
      PubTator score:  931.92  (Percentile rank: 96.24%)
      Target development/druggability level:  TchemThese targets have activities in ChEMBL or DrugCentral that satisfy the activity thresholds detailed below.
      Tractability (small molecule):  Clinical PrecedenceTargets with drugs in phase II or above; Pre-clinical targets
      Tractability (antibody):  


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