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      Official symbol:  AURKA
      Full name:  aurora kinase A
      Location:  20q13.2
      Also known as:  STK6, STK15, STK7, ARK1, PPP1R47, AurA, AIK, BTAK
      Entrez ID:  6790
      Ensembl ID:  ENSG00000087586
      Summary:  The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]


  Overall distribution
  Tissue specific distribution
Expression restricted in 10 cancer type(s)
Cancer specific in breast cancer subtype (Basal; Her2; TNBC)

  Overall distribution
  Tissue specific distribution
Gscore (Amp):  0.12  
Gscore (Del):  0.00  
Recurrently amplified in 1 cancer type(s)

  Overall distribution
  Tissue specific distribution
Mscore:  0.00  

  Tissue specific
Total fusion occurrence:  1  
Fusions detected in 1 cancer type(s)

  Tissue specific

      Functional class:  Kinase (protein kinase)
      JensenLab PubMed score:  1158.02  (Percentile rank: 96.05%)
      PubTator score:  959.65  (Percentile rank: 96.35%)
      Target development/druggability level:  TchemThese targets have activities in ChEMBL or DrugCentral that satisfy the activity thresholds detailed below.
      Tractability (small molecule):  Clinical PrecedenceTargets with drugs in phase II or above; Pre-clinical targets
      Tractability (antibody):  


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