PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
ribonucleotide reductase regulatory subunit M2ENSG00000171848RRM2chr2:10122328-10131419:+Tclin623.829
BRCA1 DNA repair associatedENSG00000012048BRCA1chr17:43044295-43125483:-Tchem6429.25
KIT proto-oncogene, receptor tyrosine kinaseENSG00000157404KITchr4:54657918-54740715:+Tclin3954.07
aurora kinase BENSG00000178999AURKBchr17:8204733-8210600:-Tchem511.747
ETS transcription factor ERGENSG00000157554ERGchr21:38380027-38661780:-Tchem2054.81
B-Raf proto-oncogene, serine/threonine kinaseENSG00000157764BRAFchr7:140719327-140924764:-Tclin4341.62
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alphaENSG00000121879PIK3CAchr3:179148114-179240093:+Tclin1264.03
melanocyte inducing transcription factorENSG00000187098MITFchr3:69739435-69968337:+Tbio449.393
fibroblast growth factor 19ENSG00000162344FGF19chr11:69698232-69704642:-Tbio162.783
cyclin A2ENSG00000145386CCNA2chr4:121816444-121823933:-Tchem957.547
tumor protein p63ENSG00000073282TP63chr3:189631416-189897279:+Tbio1791.17
HRas proto-oncogene, GTPaseENSG00000174775HRASchr11:532242-537287:-Tchem1733.76
thymidylate synthetaseENSG00000176890TYMSchr18:657604-673578:+Tclin609.544
cyclin D1ENSG00000110092CCND1chr11:69641087-69654474:+Tchem4570.69
kinesin family member 11ENSG00000138160KIF11chr10:92593286-92655395:+Tchem261.377
cyclin dependent kinase 4ENSG00000135446CDK4chr12:57747727-57756013:-Tclin1069.61
telomerase reverse transcriptaseENSG00000164362TERTchr5:1253147-1295069:-Tchem3555.38
MCL1 apoptosis regulator, BCL2 family memberENSG00000143384MCL1chr1:150574551-150579738:-Tchem1115.17
platelet derived growth factor receptor alphaENSG00000134853PDGFRAchr4:54229097-54298247:+Tclin1015.31
cyclin B1ENSG00000134057CCNB1chr5:69167010-69178245:+Tchem878.328

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