This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. [provided by RefSeq, Jul 2008]
Overall distribution
Tissue specific distribution
Expression restricted in 13 cancer type(s)
Cancer specific in breast cancer subtype (Basal; Her2; LumB; T)
Overall distribution
Tissue specific distribution
Gscore (Amp):
0.00
Gscore (Del):
0.33
Recurrently deleted in 1 cancer type(s)
Overall distribution
Tissue specific distribution
Mscore:
0.00
Overall
Tissue specific
Total fusion occurrence:
2
Fusions detected in 2 cancer type(s)
Overall
Tissue specific
CRISPR: COMMON ESSENTIAL RNAi: COMMON ESSENTIAL
Functional class:
Not specified
JensenLab PubMed score:
404.36 (Percentile rank: 89.17%)
PubTator score:
261.38 (Percentile rank: 88.45%)
Target development/druggability level:
TchemThese targets have activities in ChEMBL or DrugCentral that satisfy the activity thresholds detailed below.
Tractability (small molecule):
Clinical PrecedenceTargets with drugs in phase II or above; Pre-clinical targets
