The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). The encoded protein is necessary for proper control of the G2/M transition phase of the cell cycle. [provided by RefSeq, Aug 2017]
Overall distribution
Tissue specific distribution
Expression restricted in 21 cancer type(s)
Cancer specific in breast cancer subtype (Basal; ER; Her2; Lum)
Overall distribution
Tissue specific distribution
Gscore (Amp):
0.00
Gscore (Del):
0.88 (Driver)
Recurrently deleted in 2 cancer type(s)
Overall distribution
Tissue specific distribution
Mscore:
0.00
Overall
Tissue specific
Total fusion occurrence:
2
Fusions detected in 2 cancer type(s)
Overall
Tissue specific
CRISPR: COMMON ESSENTIAL
Functional class:
Not specified
JensenLab PubMed score:
1189.27 (Percentile rank: 96.20%)
PubTator score:
878.33 (Percentile rank: 95.97%)
Target development/druggability level:
TchemThese targets have activities in ChEMBL or DrugCentral that satisfy the activity thresholds detailed below.
Tractability (small molecule):
Discovery PrecedenceTargets with ligands; Targets with crystal structures with ligands
