Mutation

 

The putative cancer-causing CDKs and cyclins driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.

 

Summary of mutation frequency of the CDKs/cyclins in each cancer type


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 Symbol  Gene ID  ACC_Mut%  BLCA_Mut%  BRCA_Mut%  CESC_Mut%  CHOL_Mut%  COAD_Mut%  DLBC_Mut%  ESCA_Mut%  GBM_Mut%  HNSC_Mut%  KICH_Mut%  KIRC_Mut%  KIRP_Mut%  LAML_Mut%  LGG_Mut%  LIHC_Mut%  LUAD_Mut%  LUSC_Mut%  MESO_Mut%  OV_Mut%  PAAD_Mut%  PCPG_Mut%  PRAD_Mut%  READ_Mut%  SARC_Mut%  SKCM_Mut%  STAD_Mut%  TGCT_Mut%  THCA_Mut%  THYM_Mut%  UCEC_Mut%  UCS_Mut%  UVM_Mut% 
CCNF  ENSG00000162063    2.17    1.46    0.39    1.38    0    2.46    0    1.09    0.51    1.18    0    0.81    0.36    0    0.39    0.55    1.06    1.65    0    0.49    1.13    0    0.4    0.67    0.42    2.79    2.05    0    0    0    3.4    0    0  
CCNG1  ENSG00000113328    0    0.49    0    0    0    0.49    0    0    0.51    0.2    0    0    0    0    0    0.28    0.35    0    0    0    0    0    0.2    1.33    0    0.43    0    0    0    0    3.58    0    0  
CCNG2  ENSG00000138764    0    0.97    0.2    0    0    0.49    0    0    0.25    0.59    0    0.27    0.36    0    0.39    0    0    0.41    0    0    0.56    0    0.2    0    0    0.21    0.46    0    0    0    1.7    0    0  
CCNI  ENSG00000118816    0    0.97    0    0    0    0.25    0    0    0.51    0.39    0    0    0    0    0    0    0.88    0.21    0    0.24    0    0.56    0.4    2    0    0.21    0.23    0    0    0    1.89    1.75    0  
CCNI2  ENSG00000205089    1.09    0    0.2    0.35    0    0.49    0    0.54    0    0    0    0    0.71    0    0    0    0.18    0.21    0    0    0    0    0    0    0    0.43    0.23    0    0    0    0.94    1.75    0  
CCNJ  ENSG00000107443    0    0.24    0.1    0.35    0    1.23    0    0.54    0.25    0.59    0    0.54    0    0    0    0    0    0    0    0.24    0.56    0    0.2    0    0    1.29    0.68    0    0.2    0    2.64    0    0  
CCNO  ENSG00000152669    0    0.24    0.1    0    0    0.74    0    0    0    0    0    0    0    0    0    0.55    0.53    0.21    0    0.24    1.13    0    0    0    0    0    0.46    0    0    0    1.51    0    0  

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