Recurrent Alteration

Given that they occur statistically more frequently than the background, recurrent genomic alterations are considered to be under strong selective pressure and more likely play causal roles during tumorigenesis (putative therapeutic targets). To estimate the recurrent alterations of CDKs and cyclins at a pan-cancer level, we calculated an overall recurrent score via an unweighted numeric sum of the numbers of recurrent events for a given CDK or cyclin across all cancer types.