Mutation

 

The putative cancer-causing CDKs and cyclins driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.

 

Summary of mutation frequency of the CDKs/cyclins in each cancer type


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 Symbol  Gene ID  ACC_Mut%  BLCA_Mut%  BRCA_Mut%  CESC_Mut%  CHOL_Mut%  COAD_Mut%  DLBC_Mut%  ESCA_Mut%  GBM_Mut%  HNSC_Mut%  KICH_Mut%  KIRC_Mut%  KIRP_Mut%  LAML_Mut%  LGG_Mut%  LIHC_Mut%  LUAD_Mut%  LUSC_Mut%  MESO_Mut%  OV_Mut%  PAAD_Mut%  PCPG_Mut%  PRAD_Mut%  READ_Mut%  SARC_Mut%  SKCM_Mut%  STAD_Mut%  TGCT_Mut%  THCA_Mut%  THYM_Mut%  UCEC_Mut%  UCS_Mut%  UVM_Mut% 
CDK20  ENSG00000156345    0    0.73    0.2    0.35    0    0.74    0    0.54    0.25    0.2    0    0    0    0    0.2    0    0.35    0.21    0    0.24    0.56    0    0.2    2    0.85    0.86    1.37    0    0    0    2.08    0    0  
CCNA1  ENSG00000133101    0    0.97    0.29    0.69    0    4.43    0    1.63    0.25    1.38    0    0    0    2.84    0.39    0.83    1.23    0.82    0    1.21    0.56    0    0.2    0.67    0.42    3.86    2.73    0    0    0    3.77    1.75    0  
CCNA2  ENSG00000145386    0    0.73    0.49    1.04    2.78    1.23    0    0    0.51    0.2    0    0    0.36    0    0    0.28    0.71    1.03    0    0.24    0.56    0    0    0.67    0    0.21    0.46    0    0    0.81    3.4    0    0  
CCNB1  ENSG00000134057    0    0.97    0.29    0    0    1.72    0    0    0.51    0.2    0    0    0    0    0.39    0.55    0.35    0.82    0    0.24    0    0    0    0    0    0    0.46    0    0    0    2.64    0    0  
CCNB2  ENSG00000157456    0    0.24    0.2    0.35    0    0.99    0    0.54    0.25    0    0    1.36    0.36    0    0.2    0    0    0.21    0    0    0.56    0    0.2    0    0.42    0.43    0.46    0    0    0    2.45    1.75    0  
CCNC  ENSG00000112237    0    0.73    0.2    0.69    0    0.49    2.7    0.54    0.25    0    0    0    0    0    0    0.55    0.18    0    0    0    0    0    0.2    1.33    0    0.43    0.91    0    0    0    2.08    0    0  
CCND1  ENSG00000110092    0    1.22    0.1    0.69    0    0.74    0    0    0    0.39    0    0    0    0    0.78    0.28    0.53    0.82    0    0.24    0    0    0    0    0.42    0.64    0.68    0    0    0    6.79    1.75    0  
CCND2  ENSG00000118971    0    0.24    0.2    0    0    0.25    2.7    0    0.51    0.2    0    0.27    0    0    0    0.83    0.88    0.82    0    0    0.56    0    0    0    0    1.72    0.91    0    0    0    3.21    1.75    0  
CCND3  ENSG00000112576    0    1.22    0.2    0    0    0.49    2.7    0.54    0    0    0    0    0.36    0    0    0    0.18    0.41    1.22    0    0.56    0    0.2    0    0    0.64    0.23    0    0    0    1.32    0    0  
CCNE1  ENSG00000105173    0    0.73    0.2    1.04    0    1.23    0    0.54    0.51    0.59    0    0.27    0.36    0    0    0.28    0.88    0.82    0    0.49    0.56    0    0    0    0.42    1.72    1.37    0    0    0    3.96    0    0  
CCNE2  ENSG00000175305    0    1.95    0.39    0.35    0    0.99    0    0    0.51    0.79    0    0    0.36    2.13    0.2    0.55    0.53    0.21    0    0    0.56    0    0.2    1.33    0    0.64    0.68    0    0    0    3.77    1.75    0  
CCNY  ENSG00000108100    0    0.73    0.2    0.69    0    0.74    0    1.09    0.51    0.2    0    0.27    0    0    0    0    0.18    1.24    0    0    0.56    0    0    1.33    0    0.64    0.46    0    0    0    2.08    0    0  
CDK5R1  ENSG00000176749    0    0.73    0    0.35    0    1.23    2.7    0.54    0    0.2    0    0    0    0    0    0    0.53    0.21    0    0    0.56    0    0    0    0    0.43    1.14    0    0    0    2.08    0    0  
CDK5R2  ENSG00000171450    0    0.49    0    0    0    0.25    0    0    0.25    0    0    0    0    0    0    0.28    0.18    0.21    0    0.24    0    0    0    0    0.42    0.21    0.91    0    0    0    0.19    0    0  
CCNH  ENSG00000134480    0    0.73    0.2    0    0    0.49    0    0    0.76    0    0    0.27    0    0.71    0.2    0.28    0.53    0    0    0.49    0    0    0.2    1.33    0.42    0.43    0.68    0    0    0    2.83    0    0  
CCNL1  ENSG00000163660    0    0.73    0.2    1.04    0    2.71    0    0.54    0    0.2    1.52    0    0.36    0    0.2    0.28    0.18    0.82    0    0.24    1.13    0    0    2    0.42    1.29    1.37    0    0    0.81    5.28    0    0  
CCNL2  ENSG00000221978    1.09    1.7    0.59    0.69    0    1.97    0    1.63    0.76    1.18    0    0    0.36    0    0.2    0.28    0.18    0.82    1.22    0.49    0    0    0.6    0.67    0    1.72    2.73    0    0    0    3.77    0    0  
CCNT1  ENSG00000129315    0    1.7    0.69    1.38    0    2.22    0    0.54    0.76    0.79    1.52    0.27    0.36    2.13    0.2    0.55    0.88    1.24    0    1.21    0    0    0    0.67    0.42    2.15    1.82    0    0.41    0    4.91    1.75    0  
CCNT2  ENSG00000082258    0    1.22    0.1    1.38    0    1.97    0    0.54    1.02    0.59    0    0.27    0.36    0.71    0.2    0.28    1.23    0.41    0    0.73    0    0    0    2.67    0.85    1.93    0.23    0.69    0.2    0    4.72    0    0  
CCNK  ENSG00000090061    0    0.49    0.39    1.04    0    0.99    0    1.63    0.25    0.39    0    0.27    0    0    0    0    0    0.82    0    0    0.56    0    0.4    0.67    0    0.43    0.46    0.69    0    0    2.83    0    0  

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