PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
fibroblast growth factor receptor 1ENSG00000077782FGFR1chr8:38411138-38468834:-Tclin907.6
insulin like growth factor 1 receptorENSG00000140443IGF1Rchr15:98648971-98964530:+Tclin2112.4
tyrosinase related protein 1ENSG00000107165TYRP1chr9:12685439-12710290:+Tbio232.677
cadherin 1ENSG00000039068CDH1chr16:68737225-68835548:+Tbio5377.75
tumor protein p53ENSG00000141510TP53chr17:7661779-7687550:-Tchem35081.8
GNAS complex locusENSG00000087460GNASchr20:58839718-58911192:+Tbio1344.65
BCL2 like 1ENSG00000171552BCL2L1chr20:31664452-31723989:-Tchem2249.46
ATR serine/threonine kinaseENSG00000175054ATRchr3:142449235-142578826:-Tchem980.746
peroxisome proliferator activated receptor gammaENSG00000132170PPARGchr3:12287368-12434356:+Tclin4693.16
matrix metallopeptidase 1ENSG00000196611MMP1chr11:102789920-102798160:-Tchem2137.39
cyclin dependent kinase 2ENSG00000123374CDK2chr12:55966769-55972784:+Tchem1582.97
tyrosine hydroxylaseENSG00000180176THchr11:2163929-2171877:-Tclin1081.75
BUB1 mitotic checkpoint serine/threonine kinaseENSG00000169679BUB1chr2:110637698-110678114:-Tchem145.649
galanin and GMAP prepropeptideENSG00000069482GALchr11:68683779-68691175:+Tbio229.511
erb-b2 receptor tyrosine kinase 3ENSG00000065361ERBB3chr12:56079857-56103505:+Tchem726.046
MDM2 proto-oncogeneENSG00000135679MDM2chr12:68808172-68850686:+Tchem2386.9
TNF superfamily member 10ENSG00000121858TNFSF10chr3:172505508-172523507:-Tbio3727.7
AKT serine/threonine kinase 1ENSG00000142208AKT1chr14:104769349-104795751:-Tchem8060.7
phosphatase and tensin homologENSG00000171862PTENchr10:87863113-87971930:+Tbio3962.96
collagen type I alpha 2 chainENSG00000164692COL1A2chr7:94394561-94431232:+Tbio1267.1

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