Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
| Showing page 3 |
first page | previous page | next page | last page |
| KIRC | KIRP | KICH | PRAD | BLCA | THYM | MESO | LUAD | LUSC | HNSC | ESCA | STAD | COAD | READ | PAAD | LIHC | CHOL | ACC | PCPG | THCA | BRCA | OV | CESC | UCEC | UCS | SARC | TGCT | LAML | DLBC | LGG | GBM | UVM | SKCM | |||||||||||||||||||||||||||||||||||
| HGNC Symbol | Ensembl Gene ID | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del |
| CELSR3 | ENSG00000008300 | 0.00 | 0.18 | 0.00 | 0.02 | 0.05 | 0.00 | 0.00 | 0.03 | 0.03 | 0.15 | 0.00 | 0.03 | 0.00 | 0.55 | 0.01 | 0.06 | 0.00 | 0.10 | 0.00 | 0.06 | 0.01 | 0.12 | 0.01 | 0.11 | 0.00 | 0.05 | 0.02 | 0.10 | 0.00 | 0.04 | 0.03 | 0.05 | 0.00 | 0.24 | 0.01 | 0.03 | 0.01 | 0.02 | 0.00 | 0.00 | 0.01 | 0.16 | 0.10 | 0.20 | 0.01 | 0.06 | 0.06 | 0.05 | 0.11 | 0.32 | 0.03 | 0.13 | 0.02 | 0.04 | 0.00 | 0.01 | 0.00 | 0.11 | 0.01 | 0.06 | 0.02 | 0.04 | 0.00 | 0.03 | 0.02 | 0.05 |
| MGST1 | ENSG00000008394 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.03 | 0.08 | 0.02 | 0.06 | 0.01 | 0.00 | 0.00 | 0.08 | 0.08 | 0.09 | 0.13 | 0.02 | 0.05 | 0.02 | 0.08 | 0.05 | 0.04 | 0.07 | 0.02 | 0.02 | 0.06 | 0.06 | 0.02 | 0.07 | 0.02 | 0.03 | 0.14 | 0.05 | 0.02 | 0.00 | 0.00 | 0.02 | 0.00 | 0.00 | 0.07 | 0.06 | 0.23 | 0.12 | 0.01 | 0.03 | 0.04 | 0.02 | 0.19 | 0.03 | 0.13 | 0.13 | 0.58 | 0.00 | 0.00 | 0.02 | 0.00 | 0.04 | 0.03 | 0.02 | 0.02 | 0.05 | 0.00 | 0.01 | 0.02 | 0.03 |
| PGLYRP1 | ENSG00000008438 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.03 | 0.11 | 0.03 | 0.00 | 0.02 | 0.02 | 0.05 | 0.07 | 0.07 | 0.07 | 0.09 | 0.02 | 0.02 | 0.07 | 0.04 | 0.12 | 0.02 | 0.01 | 0.02 | 0.01 | 0.02 | 0.08 | 0.03 | 0.03 | 0.04 | 0.12 | 0.03 | 0.13 | 0.03 | 0.00 | 0.02 | 0.00 | 0.00 | 0.07 | 0.06 | 0.12 | 0.31 | 0.07 | 0.06 | 0.07 | 0.05 | 0.25 | 0.19 | 0.06 | 0.17 | 0.00 | 0.04 | 0.01 | 0.00 | 0.26 | 0.03 | 0.00 | 0.14 | 0.01 | 0.13 | 0.00 | 0.00 | 0.02 | 0.03 |
| ST3GAL1 | ENSG00000008513 | 0.02 | 0.00 | 0.02 | 0.00 | 0.09 | 0.00 | 0.09 | 0.01 | 0.21 | 0.03 | 0.02 | 0.00 | 0.10 | 0.04 | 0.29 | 0.01 | 0.35 | 0.01 | 0.29 | 0.00 | 0.51 | 0.01 | 0.21 | 0.01 | 0.18 | 0.01 | 0.21 | 0.02 | 0.20 | 0.00 | 0.37 | 0.01 | 0.25 | 0.01 | 0.10 | 0.00 | 0.01 | 0.02 | 0.00 | 0.01 | 0.46 | 0.03 | 1.63 | 0.03 | 0.20 | 0.00 | 0.18 | 0.01 | 0.47 | 0.03 | 0.15 | 0.06 | 0.03 | 0.02 | 0.02 | 0.00 | 0.17 | 0.00 | 0.18 | 0.01 | 0.03 | 0.02 | 0.50 | 0.00 | 0.22 | 0.01 |
| DYRK4 | ENSG00000010219 | 0.01 | 0.00 | 0.00 | 0.01 | 0.02 | 0.00 | 0.01 | 0.06 | 0.10 | 0.03 | 0.01 | 0.00 | 0.02 | 0.07 | 0.05 | 0.07 | 0.19 | 0.01 | 0.16 | 0.01 | 0.11 | 0.03 | 0.05 | 0.06 | 0.16 | 0.02 | 0.15 | 0.02 | 0.10 | 0.05 | 0.03 | 0.04 | 0.14 | 0.05 | 0.07 | 0.00 | 0.01 | 0.01 | 0.00 | 0.01 | 0.13 | 0.04 | 0.37 | 0.08 | 0.05 | 0.02 | 0.07 | 0.02 | 0.37 | 0.02 | 0.24 | 0.12 | 0.57 | 0.00 | 0.00 | 0.00 | 0.02 | 0.03 | 0.17 | 0.00 | 0.08 | 0.01 | 0.00 | 0.01 | 0.05 | 0.04 |
| CD9 | ENSG00000010278 | 0.01 | 0.00 | 0.00 | 0.01 | 0.02 | 0.00 | 0.01 | 0.07 | 0.09 | 0.02 | 0.01 | 0.00 | 0.00 | 0.08 | 0.07 | 0.07 | 0.19 | 0.02 | 0.12 | 0.01 | 0.11 | 0.03 | 0.06 | 0.05 | 0.06 | 0.02 | 0.05 | 0.03 | 0.05 | 0.05 | 0.03 | 0.04 | 0.14 | 0.05 | 0.05 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.13 | 0.04 | 0.39 | 0.07 | 0.04 | 0.02 | 0.10 | 0.02 | 0.11 | 0.03 | 0.06 | 0.13 | 0.58 | 0.00 | 0.00 | 0.00 | 0.00 | 0.05 | 0.15 | 0.01 | 0.06 | 0.02 | 0.00 | 0.01 | 0.04 | 0.04 |
| HHATL | ENSG00000010282 | 0.00 | 0.18 | 0.00 | 0.02 | 0.08 | 0.00 | 0.01 | 0.01 | 0.06 | 0.08 | 0.00 | 0.03 | 0.01 | 0.39 | 0.01 | 0.04 | 0.00 | 0.07 | 0.00 | 0.04 | 0.01 | 0.04 | 0.01 | 0.08 | 0.00 | 0.02 | 0.04 | 0.05 | 0.00 | 0.03 | 0.06 | 0.02 | 0.00 | 0.20 | 0.01 | 0.02 | 0.00 | 0.03 | 0.00 | 0.00 | 0.02 | 0.12 | 0.09 | 0.17 | 0.02 | 0.04 | 0.02 | 0.04 | 0.02 | 0.19 | 0.06 | 0.10 | 0.01 | 0.04 | 0.00 | 0.01 | 0.00 | 0.10 | 0.01 | 0.04 | 0.01 | 0.04 | 0.00 | 0.03 | 0.02 | 0.04 |
| PHF7 | ENSG00000010318 | 0.00 | 0.18 | 0.00 | 0.03 | 0.00 | 0.02 | 0.00 | 0.03 | 0.04 | 0.17 | 0.00 | 0.01 | 0.00 | 0.77 | 0.01 | 0.05 | 0.00 | 0.11 | 0.00 | 0.06 | 0.03 | 0.13 | 0.01 | 0.11 | 0.00 | 0.06 | 0.02 | 0.07 | 0.00 | 0.05 | 0.05 | 0.06 | 0.00 | 0.20 | 0.06 | 0.01 | 0.00 | 0.04 | 0.00 | 0.00 | 0.00 | 0.17 | 0.08 | 0.23 | 0.00 | 0.10 | 0.09 | 0.06 | 0.05 | 0.27 | 0.04 | 0.15 | 0.05 | 0.01 | 0.00 | 0.01 | 0.00 | 0.06 | 0.01 | 0.06 | 0.03 | 0.04 | 0.00 | 0.03 | 0.02 | 0.05 |
| SEMA3G | ENSG00000010319 | 0.00 | 0.18 | 0.00 | 0.03 | 0.00 | 0.02 | 0.00 | 0.03 | 0.04 | 0.17 | 0.00 | 0.01 | 0.00 | 0.74 | 0.01 | 0.05 | 0.00 | 0.11 | 0.00 | 0.06 | 0.02 | 0.12 | 0.01 | 0.11 | 0.00 | 0.06 | 0.02 | 0.07 | 0.00 | 0.04 | 0.05 | 0.06 | 0.00 | 0.20 | 0.15 | 0.01 | 0.00 | 0.04 | 0.00 | 0.00 | 0.00 | 0.17 | 0.08 | 0.23 | 0.00 | 0.09 | 0.09 | 0.06 | 0.05 | 0.27 | 0.04 | 0.15 | 0.05 | 0.01 | 0.00 | 0.01 | 0.00 | 0.06 | 0.01 | 0.06 | 0.03 | 0.04 | 0.00 | 0.03 | 0.02 | 0.05 |
| BTK | ENSG00000010671 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.01 | 0.04 | 0.03 | 0.00 | 0.00 | 0.00 | 0.01 | 0.03 | 0.02 | 0.09 | 0.01 | 0.04 | 0.01 | 0.08 | 0.02 | 0.04 | 0.01 | 0.02 | 0.01 | 0.01 | 0.01 | 0.00 | 0.00 | 0.02 | 0.02 | 0.00 | 0.01 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.03 | 0.06 | 0.05 | 0.03 | 0.01 | 0.02 | 0.02 | 0.01 | 0.02 | 0.09 | 0.09 | 0.00 | 0.01 | 0.00 | 0.00 | 0.04 | 0.02 | 0.02 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 |
| SLC6A7 | ENSG00000011083 | 0.31 | 0.00 | 0.02 | 0.01 | 0.03 | 0.00 | 0.02 | 0.01 | 0.03 | 0.05 | 0.00 | 0.00 | 0.02 | 0.05 | 0.04 | 0.04 | 0.01 | 0.03 | 0.01 | 0.04 | 0.04 | 0.02 | 0.03 | 0.04 | 0.02 | 0.01 | 0.04 | 0.01 | 0.02 | 0.02 | 0.10 | 0.02 | 0.09 | 0.01 | 0.26 | 0.04 | 0.00 | 0.03 | 0.01 | 0.00 | 0.04 | 0.02 | 0.18 | 0.09 | 0.02 | 0.01 | 0.04 | 0.02 | 0.11 | 0.02 | 0.07 | 0.06 | 0.00 | 0.00 | 0.00 | 0.10 | 0.04 | 0.00 | 0.00 | 0.06 | 0.01 | 0.03 | 0.00 | 0.03 | 0.04 | 0.14 |
| LARS2 | ENSG00000011376 | 0.00 | 0.18 | 0.00 | 0.02 | 0.08 | 0.00 | 0.01 | 0.02 | 0.05 | 0.09 | 0.00 | 0.03 | 0.01 | 0.49 | 0.01 | 0.06 | 0.00 | 0.08 | 0.00 | 0.05 | 0.01 | 0.07 | 0.01 | 0.09 | 0.00 | 0.04 | 0.03 | 0.06 | 0.00 | 0.04 | 0.06 | 0.03 | 0.00 | 0.24 | 0.01 | 0.02 | 0.00 | 0.02 | 0.00 | 0.00 | 0.01 | 0.14 | 0.09 | 0.17 | 0.01 | 0.05 | 0.02 | 0.05 | 0.02 | 0.20 | 0.05 | 0.12 | 0.01 | 0.04 | 0.00 | 0.01 | 0.00 | 0.12 | 0.01 | 0.04 | 0.00 | 0.04 | 0.00 | 0.03 | 0.03 | 0.05 |
| PLAUR | ENSG00000011422 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.02 | 0.00 | 0.05 | 0.14 | 0.02 | 0.00 | 0.00 | 0.08 | 0.07 | 0.12 | 0.05 | 0.12 | 0.08 | 0.03 | 0.02 | 0.07 | 0.05 | 0.08 | 0.02 | 0.02 | 0.02 | 0.02 | 0.02 | 0.09 | 0.02 | 0.04 | 0.03 | 0.12 | 0.01 | 0.17 | 0.04 | 0.00 | 0.03 | 0.00 | 0.00 | 0.06 | 0.05 | 0.18 | 0.28 | 0.18 | 0.04 | 0.04 | 0.04 | 0.09 | 0.17 | 0.13 | 0.11 | 0.00 | 0.04 | 0.01 | 0.00 | 0.07 | 0.06 | 0.02 | 0.12 | 0.04 | 0.09 | 0.00 | 0.00 | 0.02 | 0.03 |
| CD22 | ENSG00000012124 | 0.00 | 0.00 | 0.03 | 0.00 | 0.00 | 0.02 | 0.01 | 0.01 | 0.19 | 0.03 | 0.00 | 0.00 | 0.11 | 0.02 | 0.24 | 0.00 | 0.44 | 0.02 | 0.08 | 0.01 | 0.22 | 0.03 | 0.09 | 0.04 | 0.05 | 0.00 | 0.04 | 0.01 | 0.11 | 0.00 | 0.06 | 0.02 | 0.13 | 0.01 | 0.03 | 0.02 | 0.00 | 0.02 | 0.00 | 0.00 | 0.14 | 0.02 | 0.66 | 0.05 | 0.24 | 0.02 | 0.18 | 0.01 | 1.44 | 0.01 | 0.29 | 0.05 | 0.01 | 0.02 | 0.00 | 0.01 | 0.08 | 0.00 | 0.02 | 0.02 | 0.03 | 0.03 | 0.00 | 0.00 | 0.06 | 0.01 |
| NR1H4 | ENSG00000012504 | 0.01 | 0.01 | 0.02 | 0.00 | 0.06 | 0.02 | 0.05 | 0.02 | 0.06 | 0.03 | 0.00 | 0.00 | 0.01 | 0.04 | 0.02 | 0.05 | 0.01 | 0.04 | 0.02 | 0.02 | 0.04 | 0.05 | 0.04 | 0.03 | 0.01 | 0.01 | 0.01 | 0.03 | 0.00 | 0.06 | 0.06 | 0.03 | 0.00 | 0.22 | 0.00 | 0.02 | 0.00 | 0.03 | 0.00 | 0.00 | 0.04 | 0.06 | 0.09 | 0.22 | 0.01 | 0.01 | 0.02 | 0.03 | 0.02 | 0.11 | 0.37 | 0.05 | 0.00 | 0.00 | 0.00 | 0.00 | 0.08 | 0.02 | 0.01 | 0.03 | 0.01 | 0.02 | 0.00 | 0.00 | 0.01 | 0.08 |
| ALOX5 | ENSG00000012779 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.04 | 0.09 | 0.04 | 0.07 | 0.00 | 0.01 | 0.04 | 0.05 | 0.02 | 0.09 | 0.02 | 0.04 | 0.03 | 0.10 | 0.06 | 0.04 | 0.02 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.01 | 0.02 | 0.01 | 0.15 | 0.01 | 0.08 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.06 | 0.04 | 0.08 | 0.12 | 0.01 | 0.02 | 0.02 | 0.03 | 0.05 | 0.03 | 0.06 | 0.10 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.03 | 0.02 | 0.01 | 0.02 | 0.02 | 0.00 | 0.00 | 0.01 | 0.03 |
| KDM5D | ENSG00000012817 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| MAP4K5 | ENSG00000012983 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.03 | 0.03 | 0.00 | 0.01 | 0.00 | 0.05 | 0.14 | 0.01 | 0.08 | 0.05 | 0.06 | 0.02 | 0.13 | 0.05 | 0.09 | 0.02 | 0.01 | 0.01 | 0.03 | 0.02 | 0.02 | 0.01 | 0.03 | 0.08 | 0.05 | 0.28 | 0.04 | 0.01 | 0.01 | 0.01 | 0.00 | 0.00 | 0.11 | 0.03 | 0.14 | 0.14 | 0.03 | 0.02 | 0.02 | 0.02 | 0.05 | 0.03 | 0.03 | 0.11 | 0.01 | 0.00 | 0.00 | 0.00 | 0.04 | 0.00 | 0.01 | 0.02 | 0.01 | 0.04 | 0.00 | 0.00 | 0.02 | 0.03 |
| DNASE1L1 | ENSG00000013563 | 0.03 | 0.00 | 0.02 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.12 | 0.04 | 0.06 | 0.00 | 0.06 | 0.01 | 0.23 | 0.01 | 0.19 | 0.02 | 0.13 | 0.00 | 0.21 | 0.02 | 0.17 | 0.02 | 0.05 | 0.01 | 0.10 | 0.01 | 0.06 | 0.00 | 0.14 | 0.03 | 0.10 | 0.01 | 0.13 | 0.02 | 0.02 | 0.01 | 0.00 | 0.00 | 0.10 | 0.03 | 0.45 | 0.09 | 0.23 | 0.02 | 0.11 | 0.03 | 0.09 | 0.07 | 0.24 | 0.08 | 0.01 | 0.02 | 0.00 | 0.00 | 0.15 | 0.07 | 0.02 | 0.03 | 0.04 | 0.01 | 0.05 | 0.00 | 0.07 | 0.01 |
| HEBP1 | ENSG00000013583 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.17 | 0.03 | 0.08 | 0.01 | 0.00 | 0.00 | 0.06 | 0.02 | 0.09 | 0.09 | 0.02 | 0.05 | 0.03 | 0.05 | 0.04 | 0.03 | 0.09 | 0.01 | 0.04 | 0.01 | 0.09 | 0.02 | 0.06 | 0.01 | 0.06 | 0.14 | 0.05 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.06 | 0.07 | 0.25 | 0.12 | 0.01 | 0.02 | 0.03 | 0.03 | 0.04 | 0.03 | 0.11 | 0.16 | 0.54 | 0.00 | 0.00 | 0.06 | 0.00 | 0.13 | 0.03 | 0.03 | 0.00 | 0.06 | 0.00 | 0.01 | 0.04 | 0.03 |
|
Showing page 3 |
first page | previous page | next page | last page |
Copyright © 2020 University of Pennsylvania. All Rights Reserved.