Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
| Showing page 1 |
first page | previous page | next page | last page |
| KIRC | KIRP | KICH | PRAD | BLCA | THYM | MESO | LUAD | LUSC | HNSC | ESCA | STAD | COAD | READ | PAAD | LIHC | CHOL | ACC | PCPG | THCA | BRCA | OV | CESC | UCEC | UCS | SARC | TGCT | LAML | DLBC | LGG | GBM | UVM | SKCM | |||||||||||||||||||||||||||||||||||
| HGNC Symbol | Ensembl Gene ID | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del |
| CFH | ENSG00000000971 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.03 | 0.14 | 0.05 | 0.02 | 0.00 | 0.10 | 0.00 | 0.10 | 0.01 | 0.09 | 0.01 | 0.05 | 0.01 | 0.11 | 0.07 | 0.05 | 0.02 | 0.04 | 0.00 | 0.11 | 0.02 | 0.01 | 0.00 | 0.21 | 0.01 | 0.20 | 0.02 | 0.04 | 0.03 | 0.01 | 0.00 | 0.00 | 0.00 | 0.19 | 0.01 | 0.28 | 0.06 | 0.07 | 0.00 | 0.07 | 0.01 | 0.07 | 0.03 | 0.13 | 0.11 | 0.06 | 0.00 | 0.01 | 0.01 | 0.26 | 0.02 | 0.00 | 0.01 | 0.01 | 0.02 | 0.06 | 0.00 | 0.17 | 0.03 |
| FUCA2 | ENSG00000001036 | 0.00 | 0.06 | 0.00 | 0.01 | 0.00 | 0.05 | 0.01 | 0.02 | 0.06 | 0.05 | 0.00 | 0.01 | 0.00 | 0.16 | 0.02 | 0.04 | 0.05 | 0.03 | 0.04 | 0.03 | 0.09 | 0.04 | 0.11 | 0.03 | 0.02 | 0.01 | 0.03 | 0.02 | 0.01 | 0.02 | 0.01 | 0.10 | 0.00 | 0.16 | 0.16 | 0.03 | 0.00 | 0.02 | 0.00 | 0.00 | 0.10 | 0.06 | 0.05 | 0.34 | 0.01 | 0.06 | 0.04 | 0.03 | 0.08 | 0.05 | 0.42 | 0.04 | 0.01 | 0.04 | 0.00 | 0.00 | 0.00 | 0.12 | 0.00 | 0.06 | 0.00 | 0.11 | 0.05 | 0.09 | 0.01 | 0.13 |
| GCLC | ENSG00000001084 | 0.00 | 0.00 | 0.02 | 0.02 | 0.00 | 0.00 | 0.01 | 0.02 | 0.09 | 0.03 | 0.00 | 0.00 | 0.00 | 0.03 | 0.07 | 0.02 | 0.20 | 0.05 | 0.12 | 0.02 | 0.29 | 0.04 | 0.15 | 0.01 | 0.02 | 0.01 | 0.09 | 0.02 | 0.01 | 0.00 | 0.06 | 0.01 | 0.00 | 0.01 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.13 | 0.03 | 0.18 | 0.06 | 0.09 | 0.04 | 0.04 | 0.02 | 0.17 | 0.03 | 0.09 | 0.06 | 0.03 | 0.00 | 0.00 | 0.00 | 0.09 | 0.00 | 0.01 | 0.00 | 0.01 | 0.01 | 0.01 | 0.00 | 0.05 | 0.02 |
| CD99 | ENSG00000002586 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.04 | 0.01 | 0.08 | 0.07 | 0.00 | 0.00 | 0.00 | 0.00 | 0.03 | 0.07 | 0.11 | 0.07 | 0.03 | 0.03 | 0.07 | 0.12 | 0.07 | 0.04 | 0.02 | 0.02 | 0.07 | 0.08 | 0.00 | 0.00 | 0.02 | 0.04 | 0.02 | 0.01 | 0.11 | 0.00 | 0.03 | 0.00 | 0.00 | 0.00 | 0.06 | 0.05 | 0.20 | 0.20 | 0.09 | 0.02 | 0.05 | 0.04 | 0.09 | 0.11 | 0.21 | 0.11 | 0.05 | 0.02 | 0.00 | 0.00 | 0.00 | 0.07 | 0.04 | 0.02 | 0.02 | 0.01 | 0.00 | 0.01 | 0.04 | 0.02 |
| WNT16 | ENSG00000002745 | 0.01 | 0.01 | 0.10 | 0.00 | 0.01 | 0.00 | 0.02 | 0.03 | 0.04 | 0.03 | 0.00 | 0.01 | 0.05 | 0.02 | 0.06 | 0.02 | 0.10 | 0.05 | 0.04 | 0.09 | 0.06 | 0.17 | 0.07 | 0.06 | 0.02 | 0.00 | 0.01 | 0.02 | 0.03 | 0.03 | 0.08 | 0.03 | 0.00 | 0.02 | 0.00 | 0.06 | 0.00 | 0.02 | 0.00 | 0.00 | 0.06 | 0.03 | 0.33 | 0.06 | 0.03 | 0.06 | 0.02 | 0.05 | 0.13 | 0.09 | 0.11 | 0.04 | 0.03 | 0.02 | 0.00 | 0.03 | 0.09 | 0.07 | 0.10 | 0.01 | 0.05 | 0.00 | 0.00 | 0.00 | 0.16 | 0.02 |
| M6PR | ENSG00000003056 | 0.01 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.10 | 0.07 | 0.03 | 0.01 | 0.00 | 0.00 | 0.07 | 0.05 | 0.08 | 0.13 | 0.01 | 0.11 | 0.02 | 0.07 | 0.02 | 0.07 | 0.08 | 0.02 | 0.02 | 0.04 | 0.03 | 0.00 | 0.07 | 0.03 | 0.05 | 0.14 | 0.05 | 0.03 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.09 | 0.05 | 0.30 | 0.09 | 0.03 | 0.02 | 0.03 | 0.03 | 0.02 | 0.03 | 0.11 | 0.11 | 0.57 | 0.00 | 0.00 | 0.01 | 0.00 | 0.08 | 0.11 | 0.01 | 0.03 | 0.05 | 0.00 | 0.01 | 0.05 | 0.04 |
| KLHL13 | ENSG00000003096 | 0.02 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.06 | 0.03 | 0.03 | 0.00 | 0.06 | 0.01 | 0.07 | 0.01 | 0.11 | 0.01 | 0.05 | 0.02 | 0.11 | 0.02 | 0.06 | 0.03 | 0.03 | 0.01 | 0.02 | 0.01 | 0.01 | 0.00 | 0.07 | 0.02 | 0.03 | 0.01 | 0.07 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.06 | 0.02 | 0.15 | 0.06 | 0.06 | 0.01 | 0.04 | 0.02 | 0.01 | 0.03 | 0.07 | 0.12 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.02 | 0.00 | 0.01 | 0.00 | 0.00 | 0.04 | 0.01 |
| RBM5 | ENSG00000003756 | 0.00 | 0.18 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.03 | 0.03 | 0.16 | 0.02 | 0.00 | 0.00 | 0.57 | 0.01 | 0.07 | 0.00 | 0.11 | 0.00 | 0.06 | 0.02 | 0.14 | 0.01 | 0.12 | 0.00 | 0.06 | 0.01 | 0.06 | 0.00 | 0.06 | 0.06 | 0.06 | 0.00 | 0.24 | 0.01 | 0.02 | 0.00 | 0.02 | 0.00 | 0.00 | 0.01 | 0.17 | 0.08 | 0.19 | 0.01 | 0.06 | 0.09 | 0.07 | 0.02 | 0.31 | 0.03 | 0.17 | 0.02 | 0.03 | 0.00 | 0.01 | 0.00 | 0.08 | 0.02 | 0.05 | 0.02 | 0.04 | 0.00 | 0.03 | 0.01 | 0.04 |
| MTMR7 | ENSG00000003987 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.16 | 0.00 | 0.13 | 0.00 | 0.00 | 0.02 | 0.03 | 0.02 | 0.06 | 0.01 | 0.08 | 0.00 | 0.07 | 0.07 | 0.05 | 0.09 | 0.03 | 0.00 | 0.11 | 0.00 | 0.18 | 0.01 | 0.05 | 0.02 | 0.12 | 0.00 | 0.05 | 0.00 | 0.00 | 0.00 | 0.03 | 0.00 | 0.00 | 0.03 | 0.13 | 0.05 | 0.38 | 0.00 | 0.04 | 0.01 | 0.09 | 0.11 | 0.18 | 0.09 | 0.04 | 0.03 | 0.01 | 0.00 | 0.00 | 0.00 | 0.11 | 0.00 | 0.01 | 0.00 | 0.03 | 0.00 | 0.01 | 0.02 | 0.04 |
| CD38 | ENSG00000004468 | 0.01 | 0.00 | 0.01 | 0.00 | 0.02 | 0.00 | 0.01 | 0.04 | 0.04 | 0.04 | 0.00 | 0.00 | 0.00 | 0.00 | 0.04 | 0.02 | 0.03 | 0.06 | 0.02 | 0.05 | 0.04 | 0.04 | 0.04 | 0.03 | 0.01 | 0.02 | 0.03 | 0.03 | 0.00 | 0.02 | 0.04 | 0.03 | 0.00 | 0.01 | 0.04 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.03 | 0.04 | 0.16 | 0.07 | 0.01 | 0.02 | 0.07 | 0.02 | 0.06 | 0.00 | 0.08 | 0.04 | 0.04 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.01 | 0.01 | 0.05 | 0.00 | 0.03 | 0.01 |
| FKBP4 | ENSG00000004478 | 0.02 | 0.00 | 0.01 | 0.01 | 0.02 | 0.00 | 0.02 | 0.06 | 0.11 | 0.03 | 0.01 | 0.00 | 0.02 | 0.01 | 0.07 | 0.07 | 0.21 | 0.01 | 0.15 | 0.01 | 0.13 | 0.03 | 0.11 | 0.05 | 0.16 | 0.01 | 0.12 | 0.02 | 0.12 | 0.03 | 0.04 | 0.04 | 0.19 | 0.05 | 0.03 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.14 | 0.04 | 0.46 | 0.08 | 0.05 | 0.02 | 0.10 | 0.02 | 0.22 | 0.14 | 0.14 | 0.13 | 0.57 | 0.00 | 0.00 | 0.01 | 0.02 | 0.03 | 0.15 | 0.01 | 0.05 | 0.02 | 0.00 | 0.01 | 0.05 | 0.02 |
| PDK4 | ENSG00000004799 | 0.01 | 0.00 | 0.06 | 0.00 | 0.00 | 0.00 | 0.05 | 0.00 | 0.05 | 0.01 | 0.00 | 0.00 | 0.03 | 0.00 | 0.08 | 0.01 | 0.20 | 0.01 | 0.22 | 0.00 | 0.60 | 0.01 | 0.30 | 0.00 | 0.04 | 0.00 | 0.02 | 0.01 | 0.07 | 0.01 | 0.14 | 0.02 | 0.18 | 0.01 | 0.16 | 0.01 | 0.00 | 0.02 | 0.00 | 0.00 | 0.07 | 0.02 | 0.17 | 0.06 | 0.05 | 0.01 | 0.06 | 0.02 | 0.15 | 0.03 | 0.09 | 0.03 | 0.12 | 0.00 | 0.00 | 0.00 | 0.13 | 0.00 | 0.04 | 0.00 | 0.04 | 0.00 | 0.00 | 0.00 | 0.04 | 0.02 |
| SLC4A1 | ENSG00000004939 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.17 | 0.04 | 0.03 | 0.01 | 0.00 | 0.02 | 0.00 | 0.07 | 0.01 | 0.04 | 0.06 | 0.01 | 0.01 | 0.14 | 0.02 | 0.07 | 0.03 | 0.02 | 0.00 | 0.03 | 0.03 | 0.05 | 0.01 | 0.03 | 0.03 | 0.08 | 0.01 | 0.07 | 0.13 | 0.11 | 0.10 | 0.00 | 0.00 | 0.02 | 0.10 | 0.02 | 0.12 | 0.03 | 0.03 | 0.05 | 0.07 | 0.14 | 0.16 | 0.06 | 0.06 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.01 | 0.00 | 0.02 | 0.00 | 0.05 | 0.01 | 0.05 |
| CALCR | ENSG00000004948 | 0.01 | 0.00 | 0.05 | 0.00 | 0.00 | 0.00 | 0.05 | 0.00 | 0.06 | 0.02 | 0.00 | 0.00 | 0.03 | 0.01 | 0.09 | 0.01 | 0.26 | 0.00 | 0.27 | 0.01 | 0.73 | 0.01 | 0.45 | 0.01 | 0.03 | 0.00 | 0.01 | 0.01 | 0.08 | 0.00 | 0.10 | 0.02 | 0.18 | 0.01 | 0.11 | 0.01 | 0.00 | 0.05 | 0.00 | 0.00 | 0.06 | 0.02 | 0.17 | 0.06 | 0.05 | 0.01 | 0.05 | 0.02 | 0.10 | 0.03 | 0.14 | 0.03 | 0.12 | 0.00 | 0.00 | 0.00 | 0.13 | 0.00 | 0.05 | 0.00 | 0.08 | 0.00 | 0.00 | 0.02 | 0.04 | 0.02 |
| PRSS22 | ENSG00000005001 | 0.01 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.03 | 0.00 | 0.01 | 0.15 | 0.00 | 0.00 | 0.04 | 0.02 | 0.04 | 0.03 | 0.03 | 0.09 | 0.04 | 0.03 | 0.04 | 0.08 | 0.03 | 0.08 | 0.03 | 0.03 | 0.03 | 0.02 | 0.01 | 0.02 | 0.03 | 0.02 | 0.00 | 0.05 | 0.11 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.09 | 0.02 | 0.10 | 0.16 | 0.11 | 0.02 | 0.06 | 0.03 | 0.03 | 0.05 | 0.09 | 0.02 | 0.01 | 0.00 | 0.00 | 0.00 | 0.05 | 0.00 | 0.01 | 0.00 | 0.03 | 0.01 | 0.00 | 0.00 | 0.05 | 0.01 |
| SLC25A5 | ENSG00000005022 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.03 | 0.04 | 0.03 | 0.00 | 0.03 | 0.01 | 0.09 | 0.01 | 0.11 | 0.01 | 0.05 | 0.01 | 0.10 | 0.02 | 0.07 | 0.01 | 0.03 | 0.01 | 0.02 | 0.02 | 0.01 | 0.00 | 0.11 | 0.02 | 0.03 | 0.01 | 0.07 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.04 | 0.02 | 0.18 | 0.03 | 0.06 | 0.01 | 0.02 | 0.01 | 0.01 | 0.05 | 0.03 | 0.10 | 0.00 | 0.02 | 0.00 | 0.00 | 0.02 | 0.02 | 0.00 | 0.02 | 0.00 | 0.01 | 0.00 | 0.00 | 0.02 | 0.01 |
| SPPL2B | ENSG00000005206 | 0.00 | 0.01 | 0.00 | 0.02 | 0.00 | 0.02 | 0.01 | 0.04 | 0.03 | 0.12 | 0.02 | 0.00 | 0.03 | 0.10 | 0.02 | 0.08 | 0.02 | 0.12 | 0.02 | 0.13 | 0.03 | 0.15 | 0.02 | 0.08 | 0.01 | 0.05 | 0.01 | 0.10 | 0.00 | 0.07 | 0.03 | 0.13 | 0.00 | 0.03 | 0.10 | 0.01 | 0.01 | 0.00 | 0.00 | 0.01 | 0.02 | 0.16 | 0.02 | 0.90 | 0.08 | 0.19 | 0.01 | 0.27 | 0.02 | 0.75 | 0.18 | 0.15 | 0.00 | 0.00 | 0.00 | 0.01 | 0.02 | 0.03 | 0.02 | 0.02 | 0.07 | 0.01 | 0.01 | 0.02 | 0.03 | 0.06 |
| MSL3 | ENSG00000005302 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.04 | 0.00 | 0.07 | 0.04 | 0.00 | 0.00 | 0.00 | 0.00 | 0.03 | 0.05 | 0.08 | 0.06 | 0.02 | 0.02 | 0.07 | 0.04 | 0.06 | 0.02 | 0.01 | 0.01 | 0.12 | 0.02 | 0.00 | 0.01 | 0.02 | 0.02 | 0.00 | 0.01 | 0.07 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.05 | 0.03 | 0.14 | 0.18 | 0.08 | 0.00 | 0.04 | 0.02 | 0.06 | 0.07 | 0.10 | 0.06 | 0.05 | 0.01 | 0.00 | 0.00 | 0.00 | 0.04 | 0.02 | 0.01 | 0.01 | 0.03 | 0.00 | 0.00 | 0.05 | 0.02 |
| PON1 | ENSG00000005421 | 0.01 | 0.00 | 0.06 | 0.01 | 0.00 | 0.00 | 0.05 | 0.00 | 0.05 | 0.02 | 0.00 | 0.00 | 0.03 | 0.00 | 0.09 | 0.01 | 0.21 | 0.01 | 0.22 | 0.00 | 0.66 | 0.03 | 0.30 | 0.00 | 0.04 | 0.01 | 0.02 | 0.01 | 0.08 | 0.01 | 0.12 | 0.02 | 0.18 | 0.01 | 0.10 | 0.01 | 0.01 | 0.02 | 0.00 | 0.00 | 0.07 | 0.03 | 0.18 | 0.06 | 0.05 | 0.01 | 0.05 | 0.02 | 0.08 | 0.03 | 0.08 | 0.03 | 0.12 | 0.00 | 0.00 | 0.00 | 0.13 | 0.00 | 0.04 | 0.01 | 0.05 | 0.00 | 0.00 | 0.00 | 0.05 | 0.02 |
| ITGAL | ENSG00000005844 | 0.00 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.13 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.10 | 0.01 | 0.11 | 0.01 | 0.03 | 0.01 | 0.12 | 0.00 | 0.06 | 0.00 | 0.06 | 0.00 | 0.10 | 0.00 | 0.00 | 0.00 | 0.04 | 0.00 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.09 | 0.01 | 0.11 | 0.03 | 0.02 | 0.02 | 0.11 | 0.01 | 0.58 | 0.07 | 0.04 | 0.04 | 0.02 | 0.01 | 0.00 | 0.01 | 0.07 | 0.00 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.02 |
|
Showing page 1 |
first page | previous page | next page | last page |
Copyright © 2020 University of Pennsylvania. All Rights Reserved.