Transcript Fusion
The transcript fusion data of TCGA were retrieved from the TumorFusions database.
List of the transcript fusions of the CDKs/cyclins in each cancer type
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Cancer Type | TCGA_barcode | Patient | Fusion_transcript | Gene_A | Gene_B | Chr_A | Chr_B | Strand_A | Strand_B | #_Discordant_Pairs | #_JSR | #_perfect_JSR | Evalue | Junction_A | Junction_B | Tier | Frame | TN | WGS_validation | Centrality |
LGG | TCGA-TM-A84I-01A | TCGA-TM-A84I | CCNF|NOL4 | CCNF | NOL4 | 16 | 18 | 1 | -1 | 80 | 13 | 12 | 7.3 | 2489827 | 31673561 | tier1 | In-frame | 3220 | NA | 0.35728 |
BLCA | TCGA-ZF-AA4T-01A | TCGA-ZF-AA4T | CDK12|IKZF3 | CDK12 | IKZF3 | 17 | 17 | 1 | -1 | 48 | 50 | 48 | 0.067 | 37657692 | 37988404 | tier2 | Out-of-frame | 3405 | NA | 0.3724 |
BLCA | TCGA-ZF-AA4T-01A | TCGA-ZF-AA4T | CDK12|PLXDC1 | CDK12 | PLXDC1 | 17 | 17 | 1 | -1 | 9 | 6 | 5 | 0.15 | 37619370 | 37265644 | tier1 | Out-of-frame | 3408 | NA | 0.341 |
BLCA | TCGA-UY-A9PD-01A | TCGA-UY-A9PD | CDK12|TAF15 | CDK12 | TAF15 | 17 | 17 | 1 | 1 | 20 | 19 | 18 | 0.18 | 37682569 | 34169371 | tier1 | In-frame | 3410 | NA | 0.37236 |
BRCA | TCGA-3C-AALI-01A | TCGA-3C-AALI | CDK12|AC103810.1 | CDK12 | AC103810.1 | 17 | 17 | 1 | -1 | 9 | 11 | 11 | 0.13 | 37619370 | 62825367 | tier1 | CDS-5UTR | 3400 | NA | 0 |
BRCA | TCGA-C8-A12M-01A | TCGA-C8-A12M | CDK12|AKAP1 | CDK12 | AKAP1 | 17 | 17 | 1 | 1 | 10 | 15 | 14 | 1.2 | 37628016 | 55187386 | tier1 | Out-of-frame | 3401 | NA | 0.35998 |
BRCA | TCGA-3C-AALI-01A | TCGA-3C-AALI | CDK12|FAM20A | CDK12 | FAM20A | 17 | 17 | 1 | -1 | 19 | 9 | 9 | 0.36 | 37628016 | 66551884 | tier1 | In-frame | 3403 | NA | 0.33511 |
BRCA | TCGA-AO-A0JM-01A | TCGA-AO-A0JM | CDK12|FBXL20 | CDK12 | FBXL20 | 17 | 17 | 1 | -1 | 12 | 2 | 2 | 0.021 | 37628016 | 37439108 | tier1 | In-frame | 3404 | non-validated | 0.33249 |
BRCA | TCGA-EW-A6S9-01A | TCGA-EW-A6S9 | CDK12|JAK2 | CDK12 | JAK2 | 17 | 9 | 1 | 1 | 25 | 44 | 43 | 0.003 | 37628016 | 5126333 | tier1 | Out-of-frame | 3406 | NA | 0.38116 |
COAD | TCGA-AA-A02K-01A | TCGA-AA-A02K | CDK12|CACNB1 | CDK12 | CACNB1 | 17 | 17 | 1 | -1 | 16 | 12 | 10 | 0.29 | 37646986 | 37347846 | tier1 | Out-of-frame | 3402 | NA | 0.35879 |
OV | TCGA-09-1673-01A | TCGA-09-1673 | CDK12|SMG6 | CDK12 | SMG6 | 17 | 17 | 1 | -1 | 7 | 2 | 2 | 1.9 | 37657692 | 1985250 | tier1 | Out-of-frame | 3409 | NA | 0.35126 |
PRAD | TCGA-EJ-5525-01A | TCGA-EJ-5525 | CDK12|MED1 | CDK12 | MED1 | 17 | 17 | 1 | -1 | 3 | 2 | 2 | 1.7 | 37619370 | 37571592 | tier1 | Out-of-frame | 3407 | NA | 0.35216 |
BLCA | TCGA-FD-A5BR-01A | TCGA-FD-A5BR | CDK1|NRG1 | CDK1 | NRG1 | 10 | 8 | 1 | 1 | 2 | 2 | 2 | 0.75 | 62539960 | 32585467 | tier3 | In-frame | 3397 | NA | 0.37603 |
LUAD | TCGA-78-7150-01A | TCGA-78-7150 | CDK10|C16orf55 | CDK10 | C16orf55 | 16 | 16 | 1 | 1 | 39 | 32 | 21 | 3.2 | 89758924 | 89735694 | tier4 | Out-of-frame | 3398 | NA | 0 |
LUAD | TCGA-55-A48Y-01A | TCGA-55-A48Y | CDK10|SPG7 | CDK10 | SPG7 | 16 | 16 | 1 | 1 | 8 | 5 | 5 | 0.37 | 89753167 | 89611056 | tier1 | 5UTR-CDS | 3399 | NA | 0.38251 |
BLCA | TCGA-K4-A5RH-01A | TCGA-K4-A5RH | CCNL2|TYK2 | CCNL2 | TYK2 | 1 | 19 | -1 | -1 | 2 | 3 | 2 | 0.5 | 1322093 | 10491352 | tier3 | 3UTR-5UTR | 3227 | NA | 0.37934 |
BRCA | TCGA-AC-A8OR-01A | TCGA-AC-A8OR | CCNL2|RP4-758J18.6 | CCNL2 | RP4-758J18.6 | 1 | 1 | -1 | -1 | 8 | 8 | 7 | 0.81 | 1333613 | 1354929 | tier1 | In-frame | 3226 | NA | 0.36053 |
COAD | TCGA-D5-6924-01A | TCGA-D5-6924 | CCNL2|MRPL20 | CCNL2 | MRPL20 | 1 | 1 | -1 | -1 | 56 | 49 | 41 | 100 | 1333613 | 1337636 | tier1 | Out-of-frame | 3225 | NA | 0.37065 |
LUSC | TCGA-43-5670-01A | TCGA-43-5670 | MXRA8|CDK11A | MXRA8 | CDK11A | 1 | 1 | -1 | -1 | 12 | 30 | 28 | 0.26 | 1293836 | 1654270 | tier1 | CDS-5UTR | 10871 | non-validated | 0.33873 |
BLCA | TCGA-ZF-AA5H-01A | TCGA-ZF-AA5H | CBX3|CDK14 | CBX3 | CDK14 | 7 | 7 | 1 | 1 | 8 | 53 | 50 | 0.032 | 26251376 | 90836480 | tier1 | CDS-3UTR | 3085 | NA | 0.36803 |
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