Mutation

 

The putative cancer-causing CDKs and cyclins driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.

 

List of the putative cancer-causing CDKs/cyclins driven by somatic mutations in each cancer type


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 HGNC Symbol  Ensembl Gene ID  ACC  BLCA  BRCA  CESC  CHOL  COAD  DLBC  ESCA  GBM  HNSC  KICH  KIRC  KIRP  LAML  LGG  LIHC  LUAD  LUSC  MESO  OV  PAAD  PCPG  PRAD  READ  SARC  SKCM  STAD  TGCT  THCA  THYM  UCEC  UCS  UVM 
CDK20  ENSG00000156345                                                                                                                                      
CCNA1  ENSG00000133101                                                                                                                                      
CCNA2  ENSG00000145386                                                                                                                                      
CCNB1  ENSG00000134057                                                                                                                                      
CCNB2  ENSG00000157456                                                                                                                                      
CCNC  ENSG00000112237                                                                                                                                      
CCND1  ENSG00000110092                                                                                                                            1          
CCND2  ENSG00000118971                                                                                                                                      
CCND3  ENSG00000112576                                                                                                                                      
CCNE1  ENSG00000105173                                                                                                                                      
CCNE2  ENSG00000175305                                                                                                                                      
CCNY  ENSG00000108100                                                                                                                                      
CDK5R1  ENSG00000176749                                                                                                                                      
CDK5R2  ENSG00000171450                                                                                                                                      
CCNH  ENSG00000134480                                                                                                                                      
CCNL1  ENSG00000163660                                                                                                                                      
CCNL2  ENSG00000221978                                                                                                                                      
CCNT1  ENSG00000129315                                                                                                                                      
CCNT2  ENSG00000082258                                                                                                                                      
CCNK  ENSG00000090061                                                                                                                                      

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