Mutation

 

The putative cancer-causing CDKs and cyclins driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.

 

List of the putative cancer-causing CDKs/cyclins driven by somatic mutations in each cancer type


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 HGNC Symbol  Ensembl Gene ID  ACC  BLCA  BRCA  CESC  CHOL  COAD  DLBC  ESCA  GBM  HNSC  KICH  KIRC  KIRP  LAML  LGG  LIHC  LUAD  LUSC  MESO  OV  PAAD  PCPG  PRAD  READ  SARC  SKCM  STAD  TGCT  THCA  THYM  UCEC  UCS  UVM 
CDK1  ENSG00000170312                                                                                                                                      
CDK2  ENSG00000123374                                                                                                                                      
CDK3  ENSG00000250506                                                                                                                                      
CDK4  ENSG00000135446                                                                                                        1                              
CDK5  ENSG00000164885                                                                                                                                      
CDK6  ENSG00000105810                                                                    1                                                                  
CDK14  ENSG00000058091                                                                                                                                      
CDK15  ENSG00000138395                                                                                                                                      
CDK16  ENSG00000102225                                                                                                                                      
CDK17  ENSG00000059758                                                                                                                                      
CDK18  ENSG00000117266                                                                                                                                      
CDK7  ENSG00000134058                                                                                                                                      
CDK8  ENSG00000132964                                                                        1                                                              
CDK9  ENSG00000136807                                                                                                                                      
CDK10  ENSG00000185324                                                                                                                                      
CDK11A  ENSG00000008128                                                                                                                                      
CDK11B  ENSG00000248333                                                                                                        1                              
CDK12  ENSG00000167258                                                                    1            1                                            1          
CDK13  ENSG00000065883        1                                                                                                                              
CDK19  ENSG00000155111                                                                                                                                      

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