Copy Number

 

The putative cancer-causing CDKs/Cyclins driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).

 

Summary of the G-score of the CDKs/Cyclins in each cancer type


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HGNC Ensembl ACCBLCABRCACESCCHOLCOADDLBCESCAGBMHNSCKICHKIRCKIRPLAMLLGGLIHCLUADLUSCMESOOVPAADPCPGPRADREADSARCSKCMSTADTGCTTHCATHYMUCECUCSUVM
 Symbol  Gene ID  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del 
CCNF  ENSG00000162063    0.17    0.02    0.01    0.15    0.1    0.02    0.1    0.03    0    0.05    0.03    0.03    0.09    0    0.02    0.1    0.04    0.01    0.03    0.03    0    0    0.01    0    0.02    0    0    0    0.03    0    0.04    0.02    0.04    0.03    0.03    0.08    0.04    0.02    0.09    0.17    0.02    0.02    0    0.01    0.03    0    0.01    0.02    0.1    0.02    0.04    0.01    0.02    0.08    0    0    0    0    0    0    0.05    0.03    0.05    0.05    0    0  
CCNG1  ENSG00000113328    0.29    0.04    0.02    0.11    0.06    0.05    0.04    0.03    0.09    0.01    0.01    0.03    0    0    0.05    0.03    0.01    0.06    0.01    0.06    0    0    0.32    0    0.04    0.01    0    0.04    0    0.08    0.11    0.06    0.05    0.05    0.02    0.05    0.02    0.07    0.17    0.19    0.02    0.01    0    0.03    0.03    0.02    0.04    0.04    0.1    0.08    0.03    0.12    0.03    0.04    0    0.01    0.01    0    0    0    0.02    0.05    0.15    0.01    0.04    0  
CCNG2  ENSG00000138764    0.09    0    0.14    0.02    0.1    0.03    0.06    0.03    0    0.08    0.01    0.02    0    0.05    0.13    0.05    0    0.02    0.05    0.02    0    0    0.01    0    0    0.01    0    0.01    0    0.03    0.03    0.09    0.06    0.03    0.16    0.03    0    0.08    0.11    0.18    0.01    0    0.02    0.02    0.03    0.01    0.03    0.01    0.08    0.08    0.01    0.02    0.06    0.04    0.03    0.02    0    0    0    0    0.04    0.01    0.05    0.05    0    0  
CCNI  ENSG00000118816    0.09    0    0.14    0.03    0.11    0.02    0.06    0.03    0    0.08    0.01    0.02    0    0.05    0.13    0.05    0    0.01    0.06    0.02    0    0    0.01    0    0    0.01    0    0.01    0    0.03    0.03    0.09    0.06    0.03    0.17    0.03    0    0.08    0.14    0.16    0.01    0    0.02    0.02    0.03    0.01    0.03    0.01    0.08    0.07    0.01    0.02    0.06    0.04    0.03    0.02    0    0    0    0    0.04    0.01    0.05    0.05    0    0  
CCNI2  ENSG00000205089    0.32    0.02    0.04    0.04    0.03    0.04    0.02    0.04    0.09    0.01    0.01    0.05    0.04    0.02    0.03    0.06    0.02    0.02    0.01    0.05    0    0    0.28    0.01    0.03    0.01    0    0.1    0.01    0.04    0.09    0.04    0    0.08    0    0.06    0    0.05    0.11    0.19    0.01    0.04    0    0.04    0.02    0.05    0.02    0.05    0.04    0.05    0.01    0.09    0.02    0.09    0.01    0    0.01    0    0    0    0.01    0.02    0.15    0.04    0    0.03  
CCNJ  ENSG00000107443    0    0    0.02    0.1    0.03    0.08    0    0.07    0.16    0.14    0    0.09    0    0.07    0.04    0.11    0    0.05    0    0.05    0    0    0    0.01    0    0.01    0    0    0.01    0.04    0.02    0.06    0.01    0.03    0.02    0.07    0    0.16    0.08    0.31    0.01    0.03    0.01    0.01    0.01    0.12    0    0.07    0.02    0.06    0.01    0.03    0.01    0.1    0.01    0    0    0.01    0    0.02    0.02    0.1    0.03    0.09    0    0  
CCNO  ENSG00000152669    0.07    0.01    0.07    0.12    0.03    0.09    0.03    0.07    0    0.1    0.02    0.04    0    0    0.02    0.14    0    0.01    0.03    0.08    0.03    0    0    0    0.01    0    0    0.02    0    0.01    0.02    0.01    0.06    0.06    0.05    0.1    0.01    0.01    0.04    0.5    0    0.05    0    0.03    0.01    0.18    0.01    0.06    0.07    0.05    0.04    0.02    0.02    0.1    0    0.02    0    0    0    0    0.02    0.12    0.01    0.31    0    0  

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