Copy Number
The putative cancer-causing CDKs/Cyclins driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
Summary of the G-score of the CDKs/Cyclins in each cancer type
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HGNC | Ensembl | ACC | BLCA | BRCA | CESC | CHOL | COAD | DLBC | ESCA | GBM | HNSC | KICH | KIRC | KIRP | LAML | LGG | LIHC | LUAD | LUSC | MESO | OV | PAAD | PCPG | PRAD | READ | SARC | SKCM | STAD | TGCT | THCA | THYM | UCEC | UCS | UVM | |||||||||||||||||||||||||||||||||
Symbol | Gene ID | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del |
CCNF | ENSG00000162063 | 0.17 | 0.02 | 0.01 | 0.15 | 0.1 | 0.02 | 0.1 | 0.03 | 0 | 0.05 | 0.03 | 0.03 | 0.09 | 0 | 0.02 | 0.1 | 0.04 | 0.01 | 0.03 | 0.03 | 0 | 0 | 0.01 | 0 | 0.02 | 0 | 0 | 0 | 0.03 | 0 | 0.04 | 0.02 | 0.04 | 0.03 | 0.03 | 0.08 | 0.04 | 0.02 | 0.09 | 0.17 | 0.02 | 0.02 | 0 | 0.01 | 0.03 | 0 | 0.01 | 0.02 | 0.1 | 0.02 | 0.04 | 0.01 | 0.02 | 0.08 | 0 | 0 | 0 | 0 | 0 | 0 | 0.05 | 0.03 | 0.05 | 0.05 | 0 | 0 |
CCNG1 | ENSG00000113328 | 0.29 | 0.04 | 0.02 | 0.11 | 0.06 | 0.05 | 0.04 | 0.03 | 0.09 | 0.01 | 0.01 | 0.03 | 0 | 0 | 0.05 | 0.03 | 0.01 | 0.06 | 0.01 | 0.06 | 0 | 0 | 0.32 | 0 | 0.04 | 0.01 | 0 | 0.04 | 0 | 0.08 | 0.11 | 0.06 | 0.05 | 0.05 | 0.02 | 0.05 | 0.02 | 0.07 | 0.17 | 0.19 | 0.02 | 0.01 | 0 | 0.03 | 0.03 | 0.02 | 0.04 | 0.04 | 0.1 | 0.08 | 0.03 | 0.12 | 0.03 | 0.04 | 0 | 0.01 | 0.01 | 0 | 0 | 0 | 0.02 | 0.05 | 0.15 | 0.01 | 0.04 | 0 |
CCNG2 | ENSG00000138764 | 0.09 | 0 | 0.14 | 0.02 | 0.1 | 0.03 | 0.06 | 0.03 | 0 | 0.08 | 0.01 | 0.02 | 0 | 0.05 | 0.13 | 0.05 | 0 | 0.02 | 0.05 | 0.02 | 0 | 0 | 0.01 | 0 | 0 | 0.01 | 0 | 0.01 | 0 | 0.03 | 0.03 | 0.09 | 0.06 | 0.03 | 0.16 | 0.03 | 0 | 0.08 | 0.11 | 0.18 | 0.01 | 0 | 0.02 | 0.02 | 0.03 | 0.01 | 0.03 | 0.01 | 0.08 | 0.08 | 0.01 | 0.02 | 0.06 | 0.04 | 0.03 | 0.02 | 0 | 0 | 0 | 0 | 0.04 | 0.01 | 0.05 | 0.05 | 0 | 0 |
CCNI | ENSG00000118816 | 0.09 | 0 | 0.14 | 0.03 | 0.11 | 0.02 | 0.06 | 0.03 | 0 | 0.08 | 0.01 | 0.02 | 0 | 0.05 | 0.13 | 0.05 | 0 | 0.01 | 0.06 | 0.02 | 0 | 0 | 0.01 | 0 | 0 | 0.01 | 0 | 0.01 | 0 | 0.03 | 0.03 | 0.09 | 0.06 | 0.03 | 0.17 | 0.03 | 0 | 0.08 | 0.14 | 0.16 | 0.01 | 0 | 0.02 | 0.02 | 0.03 | 0.01 | 0.03 | 0.01 | 0.08 | 0.07 | 0.01 | 0.02 | 0.06 | 0.04 | 0.03 | 0.02 | 0 | 0 | 0 | 0 | 0.04 | 0.01 | 0.05 | 0.05 | 0 | 0 |
CCNI2 | ENSG00000205089 | 0.32 | 0.02 | 0.04 | 0.04 | 0.03 | 0.04 | 0.02 | 0.04 | 0.09 | 0.01 | 0.01 | 0.05 | 0.04 | 0.02 | 0.03 | 0.06 | 0.02 | 0.02 | 0.01 | 0.05 | 0 | 0 | 0.28 | 0.01 | 0.03 | 0.01 | 0 | 0.1 | 0.01 | 0.04 | 0.09 | 0.04 | 0 | 0.08 | 0 | 0.06 | 0 | 0.05 | 0.11 | 0.19 | 0.01 | 0.04 | 0 | 0.04 | 0.02 | 0.05 | 0.02 | 0.05 | 0.04 | 0.05 | 0.01 | 0.09 | 0.02 | 0.09 | 0.01 | 0 | 0.01 | 0 | 0 | 0 | 0.01 | 0.02 | 0.15 | 0.04 | 0 | 0.03 |
CCNJ | ENSG00000107443 | 0 | 0 | 0.02 | 0.1 | 0.03 | 0.08 | 0 | 0.07 | 0.16 | 0.14 | 0 | 0.09 | 0 | 0.07 | 0.04 | 0.11 | 0 | 0.05 | 0 | 0.05 | 0 | 0 | 0 | 0.01 | 0 | 0.01 | 0 | 0 | 0.01 | 0.04 | 0.02 | 0.06 | 0.01 | 0.03 | 0.02 | 0.07 | 0 | 0.16 | 0.08 | 0.31 | 0.01 | 0.03 | 0.01 | 0.01 | 0.01 | 0.12 | 0 | 0.07 | 0.02 | 0.06 | 0.01 | 0.03 | 0.01 | 0.1 | 0.01 | 0 | 0 | 0.01 | 0 | 0.02 | 0.02 | 0.1 | 0.03 | 0.09 | 0 | 0 |
CCNO | ENSG00000152669 | 0.07 | 0.01 | 0.07 | 0.12 | 0.03 | 0.09 | 0.03 | 0.07 | 0 | 0.1 | 0.02 | 0.04 | 0 | 0 | 0.02 | 0.14 | 0 | 0.01 | 0.03 | 0.08 | 0.03 | 0 | 0 | 0 | 0.01 | 0 | 0 | 0.02 | 0 | 0.01 | 0.02 | 0.01 | 0.06 | 0.06 | 0.05 | 0.1 | 0.01 | 0.01 | 0.04 | 0.5 | 0 | 0.05 | 0 | 0.03 | 0.01 | 0.18 | 0.01 | 0.06 | 0.07 | 0.05 | 0.04 | 0.02 | 0.02 | 0.1 | 0 | 0.02 | 0 | 0 | 0 | 0 | 0.02 | 0.12 | 0.01 | 0.31 | 0 | 0 |
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