Copy Number
The putative cancer-causing CDKs/Cyclins driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| HGNC | Ensembl | ACC | BLCA | BRCA | CESC | CHOL | COAD | DLBC | ESCA | GBM | HNSC | KICH | KIRC | KIRP | LAML | LGG | LIHC | LUAD | LUSC | MESO | OV | PAAD | PCPG | PRAD | READ | SARC | SKCM | STAD | TGCT | THCA | THYM | UCEC | UCS | UVM | |||||||||||||||||||||||||||||||||
| Symbol | Gene ID | PeakAmp | PeakDel | PeakAmp | PeakDel | PeakAmp | PeakDel | PeakAmp | PeakDel | PeakAmp | PeakDel | PeakAmp | PeakDel | PeakAmp | PeakDel | PeakAmp | PeakDel | PeakAmp | PeakDel | PeakAmp | PeakDel | PeakAmp | PeakDel | PeakAmp | PeakDel | PeakAmp | PeakDel | PeakAmp | PeakDel | PeakAmp | PeakDel | PeakAmp | PeakDel | PeakAmp | PeakDel | PeakAmp | PeakDel | PeakAmp | PeakDel | PeakAmp | PeakDel | PeakAmp | PeakDel | PeakAmp | PeakDel | PeakAmp | PeakDel | PeakAmp | PeakDel | PeakAmp | PeakDel | PeakAmp | PeakDel | PeakAmp | PeakDel | PeakAmp | PeakDel | PeakAmp | PeakDel | PeakAmp | PeakDel | PeakAmp | PeakDel | PeakAmp | PeakDel | PeakAmp | PeakDel |
| CCNF | ENSG00000162063 | 1 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| CCNG1 | ENSG00000113328 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| CCNG2 | ENSG00000138764 | 1 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| CCNI | ENSG00000118816 | 1 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| CCNI2 | ENSG00000205089 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| CCNJ | ENSG00000107443 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| CCNO | ENSG00000152669 | 1 | 1 | 1 | 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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