Mutation

 

The putative cancer-causing GESPs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.

 

Summary of mutation frequency of the recurrent mutated GESPs in each cancer type


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 HGNC Name  Ensembl Gene ID  HGNC Symbol  Genomic Location  ACC_Mut%  BLCA_Mut%  BRCA_Mut%  CESC_Mut%  CHOL_Mut%  COAD_Mut%  DLBC_Mut%  ESCA_Mut%  GBM_Mut%  HNSC_Mut%  KICH_Mut%  KIRC_Mut%  KIRP_Mut%  LAML_Mut%  LGG_Mut%  LIHC_Mut%  LUAD_Mut%  LUSC_Mut%  MESO_Mut%  OV_Mut%  PAAD_Mut%  PCPG_Mut%  PRAD_Mut%  READ_Mut%  SARC_Mut%  SKCM_Mut%  STAD_Mut%  TGCT_Mut%  THCA_Mut%  THYM_Mut%  UCEC_Mut%  UCS_Mut%  UVM_Mut% 
phosphoprotein membrane anchor with glycosphingolipid microdomains 1ENSG00000076641PAG1chr8:80967810-81112068:-                                                                                                                          1.55          
slingshot protein phosphatase 1ENSG00000084112SSH1chr12:108778192-108857590:-                                                                                                                          2.22          
protein kinase C alphaENSG00000154229PRKCAchr17:66302636-66810743:+                                                                  1.51                                                                  
myosin light chain kinaseENSG00000065534MYLKchr3:123610049-123884331:-                                      1.39                                                                                              
protein tyrosine phosphatase non-receptor type 4ENSG00000088179PTPN4chr2:119759631-119983818:+      2.8                                                                                                                              
FYN proto-oncogene, Src family tyrosine kinaseENSG00000010810FYNchr6:111660332-111873452:-                                                                                                      1.18                              
plasminogenENSG00000122194PLGchr6:160702238-160753315:+                                                                  4.52                                                                  
scribble planar cell polarity proteinENSG00000180900SCRIBchr8:143790920-143815379:-                                                                                                                          2.22          
catenin delta 1ENSG00000198561CTNND1chr11:57753243-57819546:+                                                                                                                          5.1          
membrane palmitoylated protein 5ENSG00000072415MPP5chr14:67241109-67335819:+      1.02                                                                                                                              
discs large MAGUK scaffold protein 1ENSG00000075711DLG1chr3:197042560-197299300:-                                                                      2.79                                                              
erbb2 interacting proteinENSG00000112851ERBB2IPchr5:65926475-66082549:+                                                                                                                          2.66          
desmoplakinENSG00000096696DSPchr6:7541575-7586717:+                                                                                                      14.22                              
anosmin 1ENSG00000011201ANOS1chrX:8528874-8732187:-                                                                                                          2.98                          
APC membrane recruitment protein 1ENSG00000184675AMER1chrX:64185117-64205744:-                      11.29                                                                                                              
angiomotinENSG00000126016AMOTchrX:112774503-112840815:-                                                                      2.79                                                              
myotubularin 1ENSG00000171100MTM1chrX:150568619-150673322:+                                                                  1.69                                                                  
spectrin repeat containing nuclear envelope protein 2ENSG00000054654SYNE2chr14:63852983-64226433:+                                                                  9.04                                                                  
xenotropic and polytropic retrovirus receptor 1ENSG00000143324XPR1chr1:180632004-180890251:+                                                                  1.69                                                                  
protein kinase N2ENSG00000065243PKN2chr1:88684222-88836255:+          0.62                                                                                                                          

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