GESPs
During the last two decades, both experimental and computational approaches have been applied to identify and predict the proteins located on cell surface membranes, although each strategy has its own limitations leading to incomplete coverage and false positives. To overcome this problem and comprehensively define the human surfaceome in the genome, we integrated GESP candidates from nine independent resources, in which the cell surface proteins were identified or predicted by distinct strategies.
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HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | Core GESP Score | Final GESP Score |
cholinergic receptor nicotinic alpha 4 subunit | ENSG00000101204 | CHRNA4 | chr20:63343223-63378401:- | 8 | 10.5 |
transmembrane serine protease 6 | ENSG00000187045 | TMPRSS6 | chr22:37065436-37109563:- | 7 | 8.5 |
T cell receptor associated transmembrane adaptor 1 | ENSG00000163519 | TRAT1 | chr3:108822698-108855005:+ | 7 | 8.5 |
mucin 13, cell surface associated | ENSG00000173702 | MUC13 | chr3:124905442-124953819:- | 7 | 8.5 |
extended synaptotagmin 3 | ENSG00000158220 | ESYT3 | chr3:138434586-138481686:+ | 8 | 9.5 |
transmembrane serine protease 11D | ENSG00000153802 | TMPRSS11D | chr4:67820876-67884032:- | 7 | 8.5 |
epiregulin | ENSG00000124882 | EREG | chr4:74365143-74388751:+ | 7 | 8.5 |
betacellulin | ENSG00000174808 | BTC | chr4:74744759-74794686:- | 7 | 9.5 |
endomucin | ENSG00000164035 | EMCN | chr4:100395341-100880126:- | 7 | 8.5 |
cadherin 18 | ENSG00000145526 | CDH18 | chr5:19472951-20575873:- | 8 | 9.5 |
cadherin 12 | ENSG00000154162 | CDH12 | chr5:21750673-22853622:- | 8 | 9.5 |
semaphorin 6A | ENSG00000092421 | SEMA6A | chr5:116443616-116574934:- | 8 | 9.5 |
multiple EGF like domains 10 | ENSG00000145794 | MEGF10 | chr5:127290831-127465737:+ | 7 | 8.5 |
protocadherin alpha 1 | ENSG00000204970 | PCDHA1 | chr5:140786136-141012347:+ | 8 | 9.5 |
protocadherin alpha 4 | ENSG00000204967 | PCDHA4 | chr5:140806929-141012344:+ | 8 | 9.5 |
protocadherin gamma subfamily A, 1 | ENSG00000204956 | PCDHGA1 | chr5:141330571-141512981:+ | 8 | 10.5 |
protocadherin gamma subfamily A, 4 | ENSG00000262576 | PCDHGA4 | chr5:141355025-141512979:+ | 8 | 9.5 |
solute carrier family 36 member 1 | ENSG00000123643 | SLC36A1 | chr5:151437046-151492381:+ | 7 | 9 |
gamma-aminobutyric acid type A receptor subunit beta2 | ENSG00000145864 | GABRB2 | chr5:161288429-161549044:- | 8 | 10.5 |
cadherin related family member 2 | ENSG00000074276 | CDHR2 | chr5:176542511-176595974:+ | 7 | 8.5 |
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