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CHRNA4  
    


    
      Official symbol:  CHRNA4
      Full name:  cholinergic receptor nicotinic alpha 4 subunit
      Location:  20q13.33
      Also known as:  BFNC, EBN, EBN1
      Entrez ID:  1137
      Ensembl ID:  ENSG00000101204
      Summary:  This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

    

    
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Gscore (Amp):  0.00  
Gscore (Del):  0.00  
 
   

    
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  Tissue specific distribution
    
 
Mscore:  0.00  
 
   

    
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Total fusion occurrence:  0  
 
 
 

    
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      Functional class:  Ion channel
      JensenLab PubMed score:  4263.66  (Percentile rank: 99.11%)
      PubTator score:  1723.69  (Percentile rank: 97.98%)
      Target development/druggability level:  TclinThese targets have activities in DrugCentral (ie. approved drugs) with known mechanism of action.
      Tractability (small molecule):  Clinical PrecedenceTargets with drugs in phase II or above; Pre-clinical targets
      Tractability (antibody):  Predicted Tractable - High confidenceTargets located in the plasma membrane; Targets with GO cell component terms plasma membrane or secreted

    







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