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Supplementary Data 1. Resources and databases used for definition of the human surfaceome

Supplementary Data 2. List of the GESPs in the human genome

Supplementary Data 3. Summary of GTEx specimens

Supplementary Data 4. Summary of TCGA specimens

Supplementary Data 5. Resources and databases used for scRNA-Seq analysis

Supplementary Data 6. Percentage of cells in each cell type expressing GESPs across 13 sc-RNASeq dataset

Supplementary Data 7. Summary of CPTAC specimens

Supplementary Data 8. List of the algorithms used to identify caGESPs

Supplementary Data 9. List of the cancer-specific GESPs (caGESPs)

Supplementary Data 10. List of the pairs identified for "AND CAR-T" strategy

Supplementary Data 11. List of the pairs identified for "iCAR-T" strategy

Supplementary Data 12. List of the putative cancer-causing GESPs driven by SCNAs in each cancer type

Supplementary Data 13. Pan-cancer level overall G-score of GESPs that recurrently gained or lost copy number in at least one cancer types

Supplementary Data 14. List of the putative cancer-causing GESPs driven by recurrent mutations in each cancer type

Supplementary Data 15. Mutation frequencies of recurrent mutated GESPs in each cancer type

Supplementary Data 16. Pan-cancer level overall M-score of GESPs that recurrently mutated in at least one cancer types

Supplementary Data 17. Summary of the mutation categories of the recurrent mutated GESPs in each cancer type

Supplementary Data 18. Summary of heterozygous and homozygous status of the recurrent mutated GESPs in each cancer type

Supplementary Data 19. Summary of timing of occurrence of the recurrent mutated GESPs in each cancer type

Supplementary Data 20. Summary of clonal and subclonal status of the recurrent mutated GESPs in each cancer type

Supplementary Data 21. List of the transcript fusions of the GESPs in each cancer type

Supplementary Data 22. Summary of the transcript fusion events of the GESPs in each cancer type

Supplementary Data 23. Summary of the recurrent transcript fusion pairs of the GESPs in each cancer type

Supplementary Data 24. List of the genomic and functional profiles for cancer cell lines

Supplementary Data 25. List of the cancer cell lines from the DepMap (Broad) and Score (Sanger) projects

Supplementary Data 26. Summary of the cell growth dependencies of the GESPs at pan-cancer level

Supplementary Data 27. Summary of the cell growth dependencies of the GESPs in each cancer type

Supplementary Data 28. Summary of association between expression/copy number and dependencies for essential GESPs

Supplementary Data 29. Resources and databases used for prediction of receptor-ligand interactions

Supplementary Data 30. Summary of the identified pairs of receptor-ligand interactions

Supplementary Data 31. Summary of the caGESP associated pairs of receptor-ligand interactions

Supplementary Data 32. List of the membrane-bound IAMs in human genome and their expression types in cancer cell lines

Supplementary Data 33. Correlation between expression levels of membrane-bound IAMs and 50 "hallmark" gene sets in cancer cell lines

Supplementary Data 34. Correlation between expression levels of membrane-bound IAMs and interferon signature score in cancer cell lines

Supplementary Data 35. Relative number of mIAMs-associated interactions among cell types in 13 scRNA-seq datasets

Supplementary Data 36. Summary of the drug development levels of GESPs

Supplementary Data 37. Summary of FDA-approved anticancer drugs targeting GESPs

Supplementary Data 38. Summary of immune therapy drugs targeting GESPs in clinical development

Supplementary Data 39. Summary of potential cancer therapeutic targets of GESPs

Supplementary Data 40. Summary of potential targets of GESPs in each cancer type









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