Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| KCNH2 | ENSG00000055118 | 0.00 | 1.02 | 0.62 | 1.09 | 2.86 | 0.65 | 0.00 | 0.00 | 0.26 | 0.80 | 0.00 | 0.27 | 0.71 | 0.74 | 0.20 | 1.11 | 2.45 | 1.50 | 1.23 | 0.49 | 0.00 | 0.00 | 0.20 | 1.56 | 0.86 | 4.03 | 1.36 | 0.00 | 0.41 | 0.00 | 3.33 | 1.82 | 0.00 |
| CD79B | ENSG00000007312 | 0.00 | 0.25 | 0.21 | 0.36 | 0.00 | 0.00 | 13.51 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.38 | 0.00 | 1.23 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| EDNRB | ENSG00000136160 | 0.00 | 1.53 | 0.31 | 0.73 | 0.00 | 1.94 | 0.00 | 1.10 | 0.00 | 1.20 | 0.00 | 0.54 | 0.36 | 0.00 | 0.00 | 0.83 | 2.26 | 3.22 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 3.13 | 0.00 | 1.90 | 5.96 | 0.00 | 0.20 | 0.00 | 0.89 | 1.82 | 0.00 |
| NKTR | ENSG00000114857 | 0.00 | 5.09 | 0.41 | 1.09 | 0.00 | 1.29 | 2.70 | 0.55 | 0.52 | 1.39 | 0.00 | 0.54 | 0.00 | 2.21 | 0.00 | 1.11 | 1.51 | 1.07 | 1.23 | 1.47 | 0.00 | 0.56 | 0.00 | 0.78 | 0.43 | 1.18 | 1.36 | 0.00 | 0.00 | 0.00 | 2.88 | 0.00 | 0.00 |
| FBN1 | ENSG00000166147 | 1.11 | 5.34 | 1.86 | 3.65 | 0.00 | 3.55 | 2.70 | 5.52 | 1.55 | 2.99 | 0.00 | 1.63 | 0.36 | 0.00 | 0.39 | 3.33 | 3.77 | 5.79 | 1.23 | 1.23 | 2.30 | 0.00 | 1.83 | 5.47 | 1.72 | 6.87 | 4.07 | 0.00 | 0.61 | 0.00 | 4.66 | 0.00 | 1.25 |
| ITGAX | ENSG00000140678 | 0.00 | 0.51 | 0.93 | 1.09 | 0.00 | 2.26 | 0.00 | 1.10 | 1.80 | 1.79 | 1.54 | 0.81 | 1.78 | 0.00 | 0.39 | 0.28 | 6.40 | 3.86 | 0.00 | 0.98 | 0.57 | 0.00 | 0.20 | 2.34 | 0.43 | 4.50 | 1.90 | 0.69 | 0.20 | 0.00 | 2.22 | 0.00 | 1.25 |
| TLN1 | ENSG00000137076 | 2.22 | 3.31 | 1.96 | 1.09 | 2.86 | 1.61 | 5.41 | 2.21 | 1.03 | 3.19 | 0.00 | 1.08 | 2.49 | 0.00 | 0.59 | 1.67 | 2.26 | 2.36 | 1.23 | 0.74 | 0.57 | 0.56 | 0.41 | 2.34 | 0.86 | 2.61 | 2.17 | 0.00 | 0.00 | 0.00 | 3.33 | 0.00 | 0.00 |
| TGFBR2 | ENSG00000163513 | 1.11 | 2.04 | 0.41 | 2.19 | 0.00 | 1.61 | 0.00 | 4.97 | 0.52 | 4.58 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.28 | 0.75 | 1.93 | 1.23 | 0.25 | 4.02 | 0.00 | 0.00 | 0.78 | 0.00 | 1.66 | 3.79 | 0.00 | 0.20 | 0.00 | 0.44 | 0.00 | 0.00 |
| FYN | ENSG00000010810 | 0.00 | 1.27 | 0.21 | 0.73 | 0.00 | 1.29 | 0.00 | 0.55 | 0.26 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.94 | 2.15 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.18 | 0.54 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| FLT4 | ENSG00000037280 | 3.33 | 2.04 | 0.10 | 1.46 | 0.00 | 2.58 | 0.00 | 0.55 | 0.52 | 2.19 | 1.54 | 0.81 | 1.07 | 0.00 | 0.78 | 1.39 | 2.82 | 3.43 | 1.23 | 0.49 | 2.87 | 0.00 | 0.41 | 1.56 | 1.72 | 5.45 | 1.90 | 0.00 | 0.20 | 0.00 | 1.77 | 0.00 | 0.00 |
| EPHA4 | ENSG00000116106 | 0.00 | 0.51 | 0.41 | 1.46 | 0.00 | 1.29 | 2.70 | 1.10 | 0.77 | 1.39 | 0.00 | 0.27 | 0.71 | 1.47 | 0.78 | 3.89 | 2.07 | 2.15 | 0.00 | 0.25 | 1.15 | 0.00 | 0.00 | 1.56 | 0.43 | 4.27 | 2.17 | 0.00 | 0.00 | 0.00 | 2.22 | 0.00 | 0.00 |
| RET | ENSG00000165731 | 1.11 | 1.27 | 0.52 | 0.36 | 0.00 | 2.58 | 0.00 | 1.10 | 1.29 | 1.79 | 0.00 | 0.27 | 0.00 | 0.00 | 0.78 | 0.28 | 3.01 | 3.22 | 0.00 | 1.96 | 0.57 | 3.37 | 0.20 | 3.13 | 1.29 | 4.50 | 2.44 | 0.00 | 0.20 | 0.00 | 1.77 | 0.00 | 1.25 |
| TGFBR1 | ENSG00000106799 | 0.00 | 1.27 | 0.31 | 0.36 | 0.00 | 1.61 | 0.00 | 1.10 | 0.26 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.28 | 0.94 | 0.86 | 0.00 | 0.25 | 1.72 | 0.00 | 0.41 | 0.78 | 0.86 | 0.24 | 1.90 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| MARK2 | ENSG00000072518 | 0.00 | 2.54 | 0.83 | 1.46 | 0.00 | 1.29 | 0.00 | 1.10 | 0.26 | 0.40 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.28 | 0.94 | 1.72 | 0.00 | 0.98 | 0.57 | 0.56 | 0.20 | 0.00 | 0.43 | 1.42 | 0.81 | 0.69 | 0.00 | 0.83 | 1.33 | 0.00 | 0.00 |
| TLR4 | ENSG00000136869 | 2.22 | 1.53 | 1.24 | 0.73 | 0.00 | 0.65 | 5.41 | 2.76 | 0.26 | 2.79 | 0.00 | 0.54 | 0.00 | 0.74 | 0.20 | 0.83 | 10.17 | 6.65 | 0.00 | 1.47 | 0.00 | 0.56 | 0.41 | 0.00 | 0.86 | 8.06 | 6.23 | 0.00 | 0.20 | 0.00 | 1.55 | 0.00 | 0.00 |
| PTPN13 | ENSG00000163629 | 1.11 | 3.82 | 0.72 | 4.01 | 0.00 | 1.61 | 2.70 | 2.21 | 0.26 | 1.99 | 0.00 | 2.17 | 0.71 | 0.00 | 0.39 | 3.06 | 3.01 | 2.58 | 0.00 | 1.23 | 1.15 | 0.56 | 0.20 | 2.34 | 0.00 | 3.08 | 3.25 | 0.00 | 0.41 | 0.00 | 3.55 | 0.00 | 0.00 |
| ADGRL3 | ENSG00000150471 | 1.11 | 4.33 | 1.45 | 2.92 | 0.00 | 3.87 | 0.00 | 1.66 | 0.52 | 3.78 | 1.54 | 1.08 | 0.71 | 0.00 | 0.78 | 3.33 | 10.17 | 10.52 | 0.00 | 1.96 | 0.00 | 0.56 | 1.63 | 5.47 | 0.43 | 6.64 | 2.98 | 0.69 | 0.20 | 0.83 | 1.77 | 1.82 | 1.25 |
| CR2 | ENSG00000117322 | 2.22 | 2.80 | 0.72 | 1.46 | 2.86 | 0.97 | 0.00 | 1.10 | 1.29 | 1.59 | 0.00 | 0.81 | 0.71 | 0.00 | 0.59 | 2.78 | 3.39 | 5.58 | 1.23 | 0.25 | 2.30 | 0.00 | 0.20 | 0.78 | 1.29 | 8.29 | 1.63 | 0.00 | 0.00 | 0.00 | 3.99 | 0.00 | 0.00 |
| EPHA5 | ENSG00000145242 | 0.00 | 4.83 | 0.93 | 2.19 | 0.00 | 4.19 | 5.41 | 3.31 | 1.29 | 4.58 | 0.00 | 1.36 | 0.36 | 0.00 | 0.98 | 0.83 | 10.55 | 8.80 | 2.47 | 1.23 | 1.15 | 0.00 | 0.00 | 4.69 | 1.29 | 2.13 | 3.52 | 0.69 | 0.00 | 0.00 | 3.33 | 5.45 | 0.00 |
| GRM7 | ENSG00000196277 | 0.00 | 2.54 | 0.21 | 1.46 | 0.00 | 3.23 | 2.70 | 1.66 | 1.03 | 2.99 | 1.54 | 0.27 | 0.00 | 0.00 | 0.39 | 1.67 | 5.84 | 3.43 | 1.23 | 0.98 | 0.00 | 0.00 | 0.20 | 4.69 | 0.86 | 10.19 | 2.98 | 0.00 | 0.00 | 0.83 | 4.21 | 3.64 | 0.00 |
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