Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| CTNNB1 | ENSG00000168036 | 15.56 | 3.05 | 0.21 | 0.73 | 0.00 | 3.87 | 0.00 | 3.31 | 0.00 | 0.80 | 0.00 | 0.27 | 0.71 | 0.00 | 0.59 | 25.83 | 3.20 | 0.43 | 0.00 | 0.25 | 1.72 | 0.00 | 2.04 | 3.13 | 0.00 | 4.74 | 4.34 | 0.00 | 0.20 | 0.83 | 22.17 | 0.00 | 0.00 |
| EGFR | ENSG00000146648 | 2.22 | 1.27 | 1.45 | 1.46 | 0.00 | 0.97 | 0.00 | 1.66 | 23.20 | 2.79 | 0.00 | 0.54 | 0.00 | 0.00 | 6.67 | 1.67 | 12.43 | 1.93 | 0.00 | 1.23 | 0.00 | 0.00 | 0.61 | 1.56 | 0.86 | 4.03 | 1.63 | 0.69 | 0.00 | 0.00 | 2.00 | 0.00 | 0.00 |
| FAT1 | ENSG00000083857 | 2.22 | 10.69 | 2.17 | 6.57 | 2.86 | 2.90 | 13.51 | 3.31 | 1.03 | 22.51 | 1.54 | 2.17 | 4.98 | 1.47 | 1.18 | 1.67 | 8.85 | 13.73 | 1.23 | 2.45 | 1.15 | 1.12 | 0.41 | 4.69 | 2.59 | 6.40 | 2.71 | 0.69 | 0.00 | 0.00 | 10.42 | 0.00 | 2.50 |
| RYR2 | ENSG00000198626 | 4.44 | 17.30 | 5.17 | 9.85 | 0.00 | 13.23 | 2.70 | 11.60 | 9.79 | 10.36 | 0.00 | 2.71 | 2.85 | 0.74 | 3.73 | 8.61 | 35.22 | 39.06 | 2.47 | 6.62 | 1.72 | 0.00 | 3.46 | 16.41 | 4.74 | 18.96 | 11.11 | 0.00 | 0.81 | 4.13 | 14.41 | 5.45 | 2.50 |
| ERBB2 | ENSG00000141736 | 0.00 | 11.20 | 2.48 | 4.01 | 2.86 | 1.61 | 0.00 | 4.42 | 0.77 | 1.79 | 0.00 | 0.81 | 1.07 | 0.74 | 0.20 | 0.28 | 1.69 | 1.72 | 0.00 | 0.98 | 0.57 | 0.00 | 0.41 | 4.69 | 0.00 | 1.42 | 3.25 | 0.69 | 0.00 | 0.00 | 3.33 | 1.82 | 0.00 |
| B2M | ENSG00000166710 | 0.00 | 0.51 | 0.31 | 1.46 | 0.00 | 1.94 | 24.32 | 0.55 | 0.26 | 1.39 | 0.00 | 0.54 | 0.36 | 0.00 | 0.00 | 0.28 | 1.13 | 1.50 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 1.66 | 0.81 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| PTPRD | ENSG00000153707 | 3.33 | 5.34 | 2.07 | 4.38 | 0.00 | 1.29 | 2.70 | 7.18 | 1.29 | 4.98 | 1.54 | 0.00 | 2.14 | 0.74 | 0.59 | 0.83 | 13.56 | 6.22 | 1.23 | 1.96 | 0.00 | 1.12 | 0.61 | 3.13 | 0.00 | 13.74 | 5.42 | 0.00 | 0.61 | 1.65 | 5.76 | 0.00 | 1.25 |
| ERBB3 | ENSG00000065361 | 0.00 | 9.92 | 1.65 | 4.01 | 0.00 | 2.90 | 0.00 | 1.10 | 1.29 | 1.99 | 0.00 | 0.54 | 0.36 | 1.47 | 0.20 | 1.67 | 2.07 | 1.50 | 0.00 | 1.47 | 0.00 | 0.00 | 0.61 | 1.56 | 0.00 | 2.13 | 4.61 | 0.00 | 0.20 | 0.00 | 5.32 | 7.27 | 0.00 |
| KIT | ENSG00000157404 | 0.00 | 1.78 | 0.52 | 0.73 | 0.00 | 1.61 | 0.00 | 2.21 | 1.03 | 1.59 | 0.00 | 0.00 | 0.00 | 2.21 | 1.18 | 2.50 | 1.13 | 3.22 | 1.23 | 1.96 | 0.00 | 0.56 | 0.20 | 3.13 | 0.86 | 3.79 | 1.63 | 14.58 | 0.20 | 0.83 | 2.88 | 0.00 | 0.00 |
| ERBB4 | ENSG00000178568 | 1.11 | 2.54 | 0.83 | 1.82 | 2.86 | 5.48 | 10.81 | 5.52 | 0.26 | 3.98 | 1.54 | 2.98 | 1.42 | 0.74 | 0.39 | 2.78 | 6.59 | 7.51 | 1.23 | 0.98 | 0.57 | 0.00 | 0.81 | 6.25 | 1.29 | 13.27 | 8.67 | 0.00 | 0.41 | 0.00 | 2.88 | 0.00 | 1.25 |
| C3 | ENSG00000125730 | 0.00 | 3.82 | 0.83 | 0.73 | 2.86 | 1.61 | 2.70 | 2.76 | 2.32 | 2.39 | 0.00 | 1.08 | 0.36 | 1.47 | 1.57 | 3.06 | 1.88 | 4.08 | 0.00 | 1.47 | 1.15 | 0.00 | 0.41 | 1.56 | 1.29 | 7.58 | 3.79 | 0.00 | 0.20 | 0.00 | 3.99 | 0.00 | 2.50 |
| MET | ENSG00000105976 | 0.00 | 4.07 | 0.62 | 0.00 | 0.00 | 0.65 | 2.70 | 1.66 | 1.29 | 0.80 | 0.00 | 0.81 | 7.83 | 0.00 | 0.59 | 0.56 | 3.20 | 1.07 | 0.00 | 0.98 | 0.00 | 0.00 | 0.61 | 0.78 | 1.72 | 5.92 | 0.00 | 0.00 | 0.20 | 0.00 | 2.66 | 1.82 | 0.00 |
| LAMA2 | ENSG00000196569 | 2.22 | 5.85 | 1.96 | 1.82 | 0.00 | 4.84 | 0.00 | 2.76 | 2.32 | 7.17 | 0.00 | 2.44 | 0.36 | 0.00 | 1.37 | 1.94 | 10.36 | 12.88 | 0.00 | 3.19 | 0.57 | 0.00 | 0.61 | 2.34 | 3.02 | 12.09 | 4.61 | 0.69 | 0.00 | 0.00 | 8.65 | 0.00 | 1.25 |
| KDR | ENSG00000128052 | 1.11 | 3.05 | 0.62 | 0.36 | 2.86 | 2.58 | 10.81 | 1.66 | 2.84 | 2.19 | 0.00 | 1.36 | 0.71 | 1.47 | 0.78 | 1.39 | 6.78 | 6.44 | 0.00 | 2.45 | 0.00 | 0.00 | 0.61 | 3.13 | 0.86 | 9.48 | 1.36 | 0.00 | 0.41 | 0.00 | 2.00 | 1.82 | 0.00 |
| FLT3 | ENSG00000122025 | 1.11 | 2.29 | 0.41 | 1.46 | 2.86 | 0.97 | 0.00 | 2.21 | 1.80 | 0.60 | 0.00 | 0.81 | 0.36 | 5.15 | 0.20 | 0.83 | 3.01 | 3.43 | 0.00 | 0.74 | 0.57 | 0.00 | 0.41 | 0.78 | 0.00 | 6.40 | 1.08 | 0.00 | 0.00 | 0.00 | 2.00 | 0.00 | 0.00 |
| A2M | ENSG00000175899 | 0.00 | 3.56 | 0.93 | 1.09 | 0.00 | 1.94 | 2.70 | 2.76 | 0.77 | 0.80 | 0.00 | 1.08 | 1.07 | 0.00 | 0.59 | 1.11 | 3.39 | 4.29 | 0.00 | 0.49 | 0.00 | 0.56 | 0.20 | 2.34 | 0.86 | 5.45 | 3.52 | 0.69 | 0.20 | 0.00 | 1.77 | 0.00 | 0.00 |
| FGFR2 | ENSG00000066468 | 0.00 | 2.04 | 1.24 | 0.73 | 8.57 | 1.29 | 2.70 | 0.00 | 0.52 | 0.60 | 0.00 | 0.54 | 0.00 | 0.74 | 0.20 | 0.83 | 1.13 | 2.79 | 0.00 | 0.98 | 0.00 | 0.56 | 0.41 | 0.00 | 0.00 | 4.50 | 1.36 | 0.00 | 0.20 | 0.00 | 10.86 | 0.00 | 1.25 |
| ACVR2A | ENSG00000121989 | 0.00 | 0.25 | 0.72 | 0.73 | 0.00 | 3.87 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.54 | 1.42 | 0.00 | 0.39 | 2.78 | 0.94 | 0.64 | 0.00 | 0.25 | 1.15 | 0.00 | 0.41 | 0.78 | 0.00 | 0.71 | 4.61 | 0.00 | 0.20 | 0.00 | 6.87 | 0.00 | 0.00 |
| FGFR3 | ENSG00000068078 | 0.00 | 13.99 | 0.00 | 0.00 | 0.00 | 1.29 | 0.00 | 0.00 | 0.52 | 1.79 | 0.00 | 0.54 | 1.78 | 0.00 | 0.00 | 0.28 | 0.56 | 1.93 | 1.23 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 2.37 | 0.81 | 0.00 | 0.00 | 0.00 | 1.11 | 1.82 | 0.00 |
| EPHA2 | ENSG00000142627 | 0.00 | 4.33 | 0.41 | 1.82 | 11.43 | 0.97 | 5.41 | 2.21 | 0.00 | 4.58 | 0.00 | 0.27 | 0.71 | 0.00 | 0.00 | 1.11 | 1.32 | 1.72 | 0.00 | 0.74 | 0.00 | 0.00 | 0.41 | 0.00 | 0.43 | 2.61 | 1.63 | 0.00 | 0.00 | 0.00 | 3.33 | 0.00 | 0.00 |
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