Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| FGFR1 | ENSG00000077782 | 0.00 | 1.02 | 0.52 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.52 | 0.40 | 0.00 | 0.81 | 0.00 | 0.00 | 0.20 | 0.28 | 0.75 | 0.43 | 1.23 | 0.74 | 0.00 | 1.12 | 0.41 | 0.00 | 0.86 | 2.61 | 0.81 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| CD180 | ENSG00000134061 | 0.00 | 1.27 | 0.10 | 1.09 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 1.08 | 1.07 | 1.47 | 0.20 | 0.00 | 0.94 | 0.86 | 0.00 | 0.49 | 0.00 | 0.56 | 0.41 | 1.56 | 0.00 | 3.32 | 0.27 | 0.69 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| CSF1R | ENSG00000182578 | 1.11 | 2.54 | 0.00 | 1.46 | 0.00 | 0.32 | 0.00 | 1.10 | 0.26 | 0.40 | 1.54 | 0.54 | 0.71 | 0.00 | 0.00 | 0.00 | 1.69 | 1.93 | 1.23 | 0.98 | 0.00 | 0.00 | 0.41 | 0.00 | 0.86 | 0.71 | 1.90 | 0.00 | 0.00 | 0.83 | 1.11 | 0.00 | 0.00 |
| BACE1 | ENSG00000186318 | 0.00 | 0.00 | 0.10 | 1.09 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.20 | 1.54 | 0.54 | 0.36 | 0.74 | 0.00 | 0.56 | 0.75 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| TFRC | ENSG00000072274 | 0.00 | 2.04 | 0.10 | 0.73 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 1.20 | 0.00 | 0.54 | 0.71 | 0.00 | 0.39 | 0.56 | 0.94 | 1.07 | 0.00 | 0.98 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.00 | 0.69 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| ECE1 | ENSG00000117298 | 1.11 | 1.27 | 0.83 | 0.00 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 0.60 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.28 | 0.94 | 1.50 | 0.00 | 1.23 | 0.00 | 0.00 | 0.41 | 0.78 | 0.00 | 3.55 | 0.54 | 0.00 | 0.00 | 0.00 | 2.44 | 0.00 | 0.00 |
| ATP1A1 | ENSG00000163399 | 0.00 | 1.78 | 0.31 | 0.36 | 0.00 | 1.61 | 0.00 | 0.55 | 0.77 | 0.80 | 0.00 | 1.08 | 1.42 | 1.47 | 0.00 | 1.11 | 0.75 | 0.21 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 1.63 | 0.69 | 0.20 | 0.00 | 0.67 | 0.00 | 0.00 |
| BACE2 | ENSG00000182240 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.56 | 0.94 | 1.07 | 0.00 | 0.49 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 1.18 | 0.54 | 0.00 | 0.00 | 0.00 | 2.00 | 0.00 | 0.00 |
| CD33 | ENSG00000105383 | 0.00 | 1.27 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.77 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.28 | 1.51 | 1.72 | 1.23 | 0.00 | 1.15 | 0.00 | 0.00 | 0.00 | 0.00 | 4.50 | 1.63 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| PTH1R | ENSG00000160801 | 0.00 | 1.27 | 0.21 | 0.36 | 2.86 | 0.00 | 0.00 | 0.55 | 0.52 | 0.80 | 0.00 | 0.81 | 0.71 | 0.74 | 0.39 | 0.00 | 1.32 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.90 | 0.54 | 0.00 | 0.00 | 0.83 | 0.89 | 0.00 | 0.00 |
| CMKLR1 | ENSG00000174600 | 0.00 | 1.02 | 0.41 | 1.09 | 0.00 | 0.65 | 0.00 | 1.10 | 0.00 | 0.60 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 0.56 | 2.82 | 1.07 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 1.56 | 0.43 | 2.13 | 0.54 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| CAMK2D | ENSG00000145349 | 0.00 | 1.02 | 0.31 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.52 | 0.60 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.56 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| ITLN1 | ENSG00000179914 | 1.11 | 0.76 | 0.10 | 0.73 | 0.00 | 0.00 | 2.70 | 0.00 | 0.52 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.56 | 1.69 | 1.29 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 2.61 | 0.00 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| PAK1 | ENSG00000149269 | 0.00 | 0.76 | 0.21 | 0.36 | 0.00 | 0.97 | 2.70 | 0.55 | 0.26 | 0.60 | 0.00 | 0.27 | 0.71 | 0.00 | 0.00 | 0.28 | 0.94 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.54 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| SLC4A7 | ENSG00000033867 | 0.00 | 1.53 | 0.52 | 0.36 | 0.00 | 0.97 | 2.70 | 1.10 | 0.52 | 1.20 | 0.00 | 0.54 | 0.36 | 2.21 | 0.39 | 1.11 | 1.88 | 1.50 | 0.00 | 1.23 | 0.00 | 0.00 | 0.61 | 0.00 | 1.29 | 1.66 | 0.27 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| CD58 | ENSG00000116815 | 0.00 | 0.25 | 0.10 | 1.09 | 0.00 | 0.32 | 8.11 | 0.00 | 0.26 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.28 | 0.19 | 0.21 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.00 | 0.43 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| HFE | ENSG00000010704 | 1.11 | 1.27 | 0.21 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.38 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 1.42 | 0.00 | 0.00 | 0.00 | 0.00 | 1.11 | 1.82 | 0.00 |
| CD109 | ENSG00000156535 | 0.00 | 2.29 | 0.83 | 0.73 | 0.00 | 2.58 | 0.00 | 1.66 | 0.26 | 1.00 | 1.54 | 0.54 | 1.07 | 0.74 | 0.00 | 1.39 | 3.20 | 3.22 | 0.00 | 1.23 | 0.00 | 0.00 | 0.00 | 2.34 | 0.00 | 2.13 | 1.90 | 0.00 | 0.20 | 0.00 | 1.55 | 0.00 | 1.25 |
| PTPRU | ENSG00000060656 | 0.00 | 2.04 | 0.72 | 1.09 | 0.00 | 1.61 | 2.70 | 1.66 | 1.29 | 1.99 | 0.00 | 0.81 | 1.07 | 0.00 | 0.20 | 0.28 | 2.64 | 1.93 | 1.23 | 0.49 | 0.00 | 0.00 | 0.81 | 0.78 | 3.02 | 2.84 | 1.90 | 0.00 | 0.00 | 0.00 | 3.55 | 0.00 | 1.25 |
| IL15RA | ENSG00000134470 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.38 | 0.00 | 0.00 | 0.25 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 1.18 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
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