Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| APP | ENSG00000142192 | 0.00 | 0.76 | 0.72 | 0.00 | 2.86 | 1.61 | 0.00 | 1.10 | 0.00 | 1.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.39 | 0.75 | 1.07 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 2.13 | 1.36 | 0.69 | 0.00 | 0.00 | 2.00 | 0.00 | 0.00 |
| EPHA1 | ENSG00000146904 | 1.11 | 0.76 | 0.41 | 0.73 | 0.00 | 0.65 | 0.00 | 0.00 | 1.29 | 1.39 | 3.08 | 0.00 | 0.00 | 0.00 | 0.00 | 0.83 | 0.94 | 1.72 | 1.23 | 1.23 | 0.57 | 0.00 | 0.41 | 0.78 | 0.43 | 3.55 | 0.27 | 0.00 | 0.00 | 0.00 | 2.66 | 0.00 | 0.00 |
| EPHA7 | ENSG00000135333 | 0.00 | 2.54 | 0.72 | 1.09 | 2.86 | 1.29 | 5.41 | 2.76 | 1.29 | 3.78 | 0.00 | 0.27 | 0.36 | 0.00 | 0.39 | 1.39 | 4.71 | 3.43 | 1.23 | 1.72 | 1.15 | 0.00 | 0.41 | 1.56 | 1.29 | 7.11 | 2.71 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| LILRB2 | ENSG00000131042 | 2.22 | 0.76 | 0.21 | 0.73 | 0.00 | 1.29 | 0.00 | 0.00 | 1.80 | 1.20 | 0.00 | 0.27 | 0.00 | 0.74 | 0.78 | 0.00 | 4.33 | 2.36 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 6.16 | 0.27 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| ITGAV | ENSG00000138448 | 0.00 | 3.05 | 1.03 | 0.36 | 0.00 | 1.61 | 0.00 | 1.66 | 0.00 | 0.80 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.56 | 1.51 | 1.29 | 0.00 | 0.49 | 0.00 | 0.56 | 0.20 | 0.78 | 0.43 | 1.66 | 2.71 | 0.00 | 0.20 | 0.00 | 2.00 | 0.00 | 0.00 |
| SLC6A9 | ENSG00000196517 | 0.00 | 1.27 | 0.31 | 1.09 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.80 | 0.00 | 0.00 | 0.36 | 0.74 | 0.00 | 0.00 | 1.32 | 0.21 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 1.42 | 0.54 | 0.00 | 0.20 | 0.00 | 1.33 | 0.00 | 0.00 |
| ANTXR2 | ENSG00000163297 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 1.54 | 0.00 | 0.71 | 0.74 | 0.00 | 0.28 | 0.56 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 0.95 | 0.27 | 0.69 | 0.20 | 0.00 | 1.11 | 0.00 | 0.00 |
| TRPV2 | ENSG00000187688 | 0.00 | 0.76 | 0.52 | 1.46 | 0.00 | 0.00 | 0.00 | 1.10 | 0.52 | 0.60 | 0.00 | 0.00 | 0.71 | 0.00 | 0.39 | 0.56 | 1.32 | 0.86 | 0.00 | 0.98 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 0.71 | 0.54 | 0.00 | 0.20 | 0.00 | 2.22 | 0.00 | 1.25 |
| PTK7 | ENSG00000112655 | 0.00 | 1.02 | 0.62 | 1.09 | 0.00 | 0.65 | 0.00 | 0.55 | 1.55 | 0.60 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 0.00 | 1.69 | 1.29 | 0.00 | 0.98 | 0.00 | 0.00 | 0.81 | 0.78 | 0.00 | 4.50 | 0.27 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| SLC38A1 | ENSG00000111371 | 0.00 | 0.51 | 0.31 | 0.36 | 0.00 | 0.00 | 0.00 | 1.10 | 0.77 | 0.60 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.56 | 0.56 | 0.86 | 0.00 | 0.49 | 0.00 | 0.00 | 0.41 | 0.78 | 0.43 | 3.08 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| LRP1 | ENSG00000123384 | 5.56 | 6.62 | 1.76 | 2.19 | 5.71 | 2.58 | 0.00 | 1.66 | 3.35 | 5.18 | 0.00 | 2.98 | 1.78 | 1.47 | 1.57 | 5.00 | 5.84 | 6.01 | 2.47 | 4.17 | 2.30 | 0.56 | 0.81 | 3.13 | 2.59 | 7.35 | 2.98 | 0.00 | 0.41 | 0.00 | 9.76 | 5.45 | 0.00 |
| RIPK1 | ENSG00000137275 | 0.00 | 1.78 | 0.41 | 0.36 | 0.00 | 0.97 | 0.00 | 0.00 | 0.52 | 0.40 | 0.00 | 0.27 | 0.36 | 0.00 | 0.39 | 0.56 | 1.13 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.86 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| HLA-DRA | ENSG00000204287 | 0.00 | 1.02 | 0.00 | 0.36 | 2.86 | 0.65 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 0.00 | 0.19 | 1.29 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.90 | 0.54 | 0.00 | 0.20 | 0.00 | 0.00 | 1.82 | 0.00 |
| ACE | ENSG00000159640 | 0.00 | 2.04 | 0.62 | 0.00 | 0.00 | 0.97 | 0.00 | 1.66 | 1.55 | 1.39 | 0.00 | 0.54 | 1.78 | 0.74 | 0.78 | 0.83 | 1.69 | 1.93 | 0.00 | 0.49 | 0.57 | 0.00 | 0.41 | 1.56 | 0.00 | 5.45 | 0.54 | 0.69 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| SLC2A3 | ENSG00000059804 | 1.11 | 1.53 | 0.41 | 0.00 | 0.00 | 0.65 | 0.00 | 0.55 | 0.77 | 0.20 | 0.00 | 1.08 | 0.00 | 0.00 | 0.20 | 0.56 | 1.69 | 2.36 | 0.00 | 1.23 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 1.42 | 0.54 | 0.69 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| ITGB1 | ENSG00000150093 | 0.00 | 0.76 | 0.41 | 1.09 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 2.19 | 1.54 | 1.08 | 0.36 | 0.00 | 0.00 | 0.28 | 0.94 | 1.72 | 0.00 | 0.00 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 0.47 | 0.81 | 0.00 | 0.41 | 0.00 | 1.11 | 1.82 | 0.00 |
| IL1R1 | ENSG00000115594 | 0.00 | 0.25 | 0.41 | 0.36 | 0.00 | 0.65 | 0.00 | 1.10 | 0.77 | 0.80 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 1.39 | 0.19 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 3.32 | 0.00 | 0.00 | 0.20 | 0.00 | 0.89 | 1.82 | 1.25 |
| PRKCH | ENSG00000027075 | 1.11 | 0.51 | 0.31 | 0.00 | 0.00 | 0.97 | 0.00 | 1.10 | 0.52 | 0.60 | 0.00 | 1.08 | 0.00 | 0.00 | 0.00 | 0.56 | 0.75 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.90 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| KCNK10 | ENSG00000100433 | 1.11 | 1.02 | 0.10 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.77 | 0.60 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.56 | 2.26 | 4.08 | 0.00 | 0.98 | 0.00 | 0.00 | 0.41 | 0.00 | 1.29 | 4.74 | 0.81 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| FES | ENSG00000182511 | 0.00 | 0.25 | 0.52 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 1.20 | 0.00 | 0.81 | 0.36 | 0.00 | 0.39 | 0.28 | 0.00 | 0.43 | 1.23 | 0.00 | 0.00 | 0.00 | 0.41 | 0.78 | 0.43 | 1.90 | 0.81 | 0.00 | 0.00 | 0.83 | 1.11 | 0.00 | 0.00 |
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