PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
catalaseENSG00000121691CATchr11:34438925-34472062:+Tbio7740.29
lysyl oxidaseENSG00000113083LOXchr5:122063195-122078285:-Tbio523.491
polo like kinase 4ENSG00000142731PLK4chr4:127880861-127899195:+Tchem107.258
sphingosine kinase 1ENSG00000176170SPHK1chr17:76376584-76387860:+Tchem400.594
ALK receptor tyrosine kinaseENSG00000171094ALKchr2:29192774-29921566:-Tclin1838.9
serpin family E member 2ENSG00000135919SERPINE2chr2:223975112-224039319:-Tbio632.632
PRAME nuclear receptor transcriptional regulatorENSG00000185686PRAMEchr22:22547701-22559361:-Tbio138.226
ATP binding cassette subfamily B member 1ENSG00000085563ABCB1chr7:87503633-87713323:-Tchem9526.17
solute carrier family 7 member 5ENSG00000103257SLC7A5chr16:87830023-87869488:-Tbio214.168
G protein-coupled estrogen receptor 1ENSG00000164850GPER1chr7:1082208-1093815:+Tchem333.461
DNA polymerase epsilon, catalytic subunitENSG00000177084POLEchr12:132623753-132687365:-Tclin15.75
matrix metallopeptidase 3ENSG00000149968MMP3chr11:102835801-102843803:-Tchem1264.94
lamin A/CENSG00000160789LMNAchr1:156082573-156140089:+Tbio1343.55
NFKB inhibitor alphaENSG00000100906NFKBIAchr14:35401511-35404749:-Tchem1533.46
Janus kinase 3ENSG00000105639JAK3chr19:17824780-17848071:-Tclin330.397
anterior gradient 2, protein disulphide isomerase family memberENSG00000106541AGR2chr7:16791811-16833433:-Tbio246.261
matrix metallopeptidase 10ENSG00000166670MMP10chr11:102770503-102780628:-Tchem210.291
Raf-1 proto-oncogene, serine/threonine kinaseENSG00000132155RAF1chr3:12583601-12664226:-Tclin1317.37
trio Rho guanine nucleotide exchange factorENSG00000038382TRIOchr5:14143702-14532128:+Tbio188.079
peptidase inhibitor 3ENSG00000124102PI3chr20:45174876-45176544:+Tbio253.888

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