PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
complement factor HENSG00000000971CFHchr1:196651878-196747504:+Tbio1692.38
CF transmembrane conductance regulatorENSG00000001626CFTRchr7:117465784-117715971:+Tclin5925.49
nuclear factor kappa B subunit 1ENSG00000109320NFKB1chr4:102501329-102617302:+Tchem7253.87
thrombospondin 1ENSG00000137801THBS1chr15:39581079-39599466:+Tbio1805.1
ASH1 like histone lysine methyltransferaseENSG00000116539ASH1Lchr1:155335268-155562807:-Tbio25.3099
parathyroid hormone like hormoneENSG00000087494PTHLHchr12:27958084-27972705:-Tbio1391.48
phosphodiesterase 4DENSG00000113448PDE4Dchr5:58969038-60522120:-Tclin230.075
MDM4 regulator of p53ENSG00000198625MDM4chr1:204516379-204558120:+Tchem187.724
heat shock protein family D (Hsp60) member 1ENSG00000144381HSPD1chr2:197486581-197516737:-Tbio2042.65
DNA polymerase delta 1, catalytic subunitENSG00000062822POLD1chr19:50384204-50418018:+Tclin226.453
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit deltaENSG00000171608PIK3CDchr1:9651732-9729114:+Tclin2885.84
platelet derived growth factor subunit AENSG00000197461PDGFAchr7:497258-520296:-Tchem336.766
carbonic anhydrase 9ENSG00000107159CA9chr9:35673856-35681159:+Tclin820.218
EPH receptor B2ENSG00000133216EPHB2chr1:22710839-22921500:+Tchem282.556
transmembrane serine protease 2ENSG00000184012TMPRSS2chr21:41464551-41531116:-Tchem388.203
syndecan 1ENSG00000115884SDC1chr2:20200797-20225433:-Tbio901.295
secreted phosphoprotein 1ENSG00000118785SPP1chr4:87975650-87983426:+Tbio3127.99
cellular retinoic acid binding protein 2ENSG00000143320CRABP2chr1:156699606-156705816:-Tbio137.255
eukaryotic translation initiation factor 4EENSG00000151247EIF4Echr4:98871684-98930637:-Tchem796.366
toll like receptor 3ENSG00000164342TLR3chr4:186069152-186088069:+Tbio792.061

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