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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
TNF superfamily member 11	ENSG00000120659	TNFSF11	chr13:42562736-42608013:+	Tclin	1951.46
thioredoxin	ENSG00000136810	TXN	chr9:110243811-110256640:-	Tchem	1655.38
relaxin 2	ENSG00000107014	RLN2	chr9:5299868-5304969:-	Tbio	1166.09
stratifin	ENSG00000175793	SFN	chr1:26863138-26864457:+	Tbio	175.69
mucin 1, cell surface associated	ENSG00000185499	MUC1	chr1:155185824-155192916:-	Tbio	2933.59
EPH receptor A2	ENSG00000142627	EPHA2	chr1:16124337-16156087:-	Tclin	341.83
MPL proto-oncogene, thrombopoietin receptor	ENSG00000117400	MPL	chr1:43337807-43352772:+	Tclin	602.959
inositol polyphosphate-5-phosphatase D	ENSG00000168918	INPP5D	chr2:233059967-233207903:+	Tbio	1598.21
mechanistic target of rapamycin kinase	ENSG00000198793	MTOR	chr1:11106535-11262507:-	Tclin	4386.42
cell division cycle 25C	ENSG00000158402	CDC25C	chr5:138285265-138338355:-	Tchem	477.456
C-X-C motif chemokine ligand 8	ENSG00000169429	CXCL8	chr4:73740506-73743716:+	Tchem	11179.4
matrix metallopeptidase 11	ENSG00000099953	MMP11	chr22:23768226-23784316:+	Tchem	152.869
matrix metallopeptidase 7	ENSG00000137673	MMP7	chr11:102520508-102530753:-	Tchem	722.285
solute carrier family 6 member 3	ENSG00000142319	SLC6A3	chr5:1392790-1445430:-	Tclin	2895.84
hepatocyte nuclear factor 4 alpha	ENSG00000101076	HNF4A	chr20:44355700-44434596:+	Tchem	1022.57
cell division cycle 7	ENSG00000097046	CDC7	chr1:91500893-91525764:+	Tchem	90.9542
epithelial cell adhesion molecule	ENSG00000119888	EPCAM	chr2:47345158-47387601:+	Tbio	915.081
mitogen-activated protein kinase kinase 1	ENSG00000169032	MAP2K1	chr15:66386817-66492312:+	Tclin	555.587
collagen type I alpha 1 chain	ENSG00000108821	COL1A1	chr17:50183289-50201632:-	Tbio	744.022
alpha fetoprotein	ENSG00000081051	AFP	chr4:73431138-73456174:+	Tbio	10421.1

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