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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
cyclin E2	ENSG00000175305	CCNE2	chr8:94879770-94896678:-	Tbio	51.6481
CD79a molecule	ENSG00000105369	CD79A	chr19:41877120-41881372:+	Tbio	1341.52
ABL proto-oncogene 1, non-receptor tyrosine kinase	ENSG00000097007	ABL1	chr9:130713946-130887675:+	Tclin	4611.85
matrix metallopeptidase 13	ENSG00000137745	MMP13	chr11:102942995-102955734:-	Tchem	649.812
LIF interleukin 6 family cytokine	ENSG00000128342	LIF	chr22:30240447-30246851:-	Tbio	2397.27
MDS1 and EVI1 complex locus	ENSG00000085276	MECOM	chr3:169083499-169663618:-	Tbio	231.847
Kruppel like factor 5	ENSG00000102554	KLF5	chr13:73054976-73077542:+	Tbio	139.185
ISG15 ubiquitin like modifier	ENSG00000187608	ISG15	chr1:1001138-1014541:+	Tbio	246.04
cyclin D3	ENSG00000112576	CCND3	chr6:41934933-42050357:-	Tchem	253.497
REL proto-oncogene, NF-kB subunit	ENSG00000162924	REL	chr2:60881521-60931610:+	Tbio	473.424
ATPase family AAA domain containing 2	ENSG00000156802	ATAD2	chr8:123319850-123416350:-	Tchem	73.2974
LCK proto-oncogene, Src family tyrosine kinase	ENSG00000182866	LCK	chr1:32251239-32286165:+	Tclin	874.303
cell division cycle 25A	ENSG00000164045	CDC25A	chr3:48157146-48188402:-	Tchem	246.053
transferrin receptor	ENSG00000072274	TFRC	chr3:196027183-196082189:-	Tbio	1690.68
protein tyrosine kinase 2	ENSG00000169398	PTK2	chr8:140657900-141002216:-	Tchem	1563.61
tyrosinase	ENSG00000077498	TYR	chr11:89177452-89295759:+	Tclin	2933.65
BCR activator of RhoGEF and GTPase	ENSG00000186716	BCR	chr22:23179704-23318037:+	Tclin	560.596
anoctamin 1	ENSG00000131620	ANO1	chr11:70078302-70189528:+	Tclin	233.435
KISS1 receptor	ENSG00000116014	KISS1R	chr19:917287-921015:+	Tchem	214.452
cadherin 2	ENSG00000170558	CDH2	chr18:27950966-28177446:-	Tbio	909.184

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