PDGs
The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .
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| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | TDL | PubTator Score |
| olfactory receptor family 10 subfamily R member 3 pseudogene | ENSG00000198703 | OR10R3P | chr1:158491219-158492160:+ | 0 | |
| caspase 12 (gene/pseudogene) | ENSG00000204403 | CASP12 | chr11:104885718-104898670:- | Tbio | 32.7714 |
| olfactory receptor family 2 subfamily J member 1 | ENSG00000204702 | OR2J1 | chr6:29100609-29101881:+ | Tdark | 0.333333 |
| PRSS3 pseudogene 4 | ENSG00000204982 | PRSS3P4 | chr9:33613848-33614009:- | Tchem | 30.0873 |
| olfactory receptor family 10 subfamily C member 1 | ENSG00000206474 | OR10C1 | chr6:29439306-29440977:+ | Tdark | 1 |
| olfactory receptor family 2 subfamily F member 1 | ENSG00000213215 | OR2F1 | chr7:143959927-143961015:+ | Tdark | 0.5 |
| olfactory receptor family 7 subfamily E member 5 pseudogene | ENSG00000214880 | OR7E5P | chr11:55979398-55980103:- | 0 | |
| matrix metallopeptidase 23A (pseudogene) | ENSG00000215914 | MMP23A | chr1:1699942-1701782:+ | 0 | |
| olfactory receptor family 1 subfamily F member 12 | ENSG00000220721 | OR1F12 | chr6:28073316-28074233:+ | Tdark | 0 |
| killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 4 | ENSG00000221957 | KIR2DS4 | chr19:54832676-54848569:+ | Tdark | 57.4551 |
| olfactory receptor family 52 subfamily B member 4 | ENSG00000221996 | OR52B4 | chr11:4367263-4368386:- | Tdark | 0 |
| olfactory receptor family 2 subfamily H member 5 pseudogene | ENSG00000232173 | OR2H5P | chr6:29573909-29574836:+ | 0 | |
| solute carrier family 35 member G4 | ENSG00000236396 | SLC35G4 | chr18:11609596-11610612:+ | Tdark | 0 |
| ATP binding cassette subfamily C member 13 (pseudogene) | ENSG00000243064 | ABCC13 | chr21:14236206-14362754:+ | Tdark | 3 |
| olfactory receptor family 7 subfamily E member 85 pseudogene | ENSG00000250884 | OR7E85P | chr4:9483718-9484702:+ | 0 | |
| olfactory receptor family 1 subfamily D member 4 | ENSG00000255095 | OR1D4 | chr17:3240676-3241614:+ | Tdark | 0 |
| cytochrome b5 type A pseudogene 3 | ENSG00000258595 | RP11-371E8.2 | chr14:93138066-93138465:+ | 0 | |
| serpin family A member 2 (gene/pseudogene) | ENSG00000258597 | SERPINA2 | chr14:94363714-94366698:- | Tdark | 2.83333 |
| olfactory receptor family 11 subfamily H member 7 (gene/pseudogene) | ENSG00000258806 | OR11H7 | chr14:20229402-20230341:+ | Tdark | 1 |
| olfactory receptor family 4 subfamily C member 45 (gene/pseudogene) | ENSG00000260811 | OR4C45 | chr11:50032874-50033794:+ | Tdark | 0 |
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