PDGs
The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .
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| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | TDL | PubTator Score |
| dopamine receptor D5 pseudogene 2 | ENSG00000175658 | DRD5P2 | chr1:144274892-144277993:- | 0 | |
| olfactory receptor family 4 subfamily H member 12 pseudogene | ENSG00000176312 | OR4H12P | chr14:19759868-19760774:+ | 0 | |
| olfactory receptor family 10 subfamily AC member 1 (gene/pseudogene) | ENSG00000176510 | OR10AC1 | chr7:143510933-143511911:- | Tdark | 0 |
| olfactory receptor family 52 subfamily Z member 1 | ENSG00000176748 | OR52Z1 | chr11:5177714-5178610:- | Tdark | 0 |
| olfactory receptor family 7 subfamily E member 125 pseudogene | ENSG00000177306 | OR7E125P | chr8:7246726-7247571:- | 0 | |
| olfactory receptor family 7 subfamily E member 8 pseudogene | ENSG00000177400 | OR7E8P | chr8:12684154-12685153:- | 0 | |
| trace amine associated receptor 3, pseudogene | ENSG00000179073 | TAAR3 | chr6:132608225-132609302:- | Tdark | 1.25 |
| olfactory receptor family 6 subfamily W member 1 pseudogene | ENSG00000179420 | OR6W1P | chr7:143062330-143063585:- | 0 | |
| olfactory receptor family 3 subfamily A member 4 pseudogene | ENSG00000180068 | OR3A4P | chr17:3310312-3311189:+ | Tdark | 0.25 |
| olfactory receptor family 6 subfamily K member 4 pseudogene | ENSG00000180437 | OR6K4P | chr1:158724113-158725067:- | 0 | |
| olfactory receptor family 8 subfamily G member 2 pseudogene | ENSG00000181214 | OR8G2P | chr11:124224732-124225639:+ | Tdark | 0.125 |
| olfactory receptor family 5 subfamily AK member 3 pseudogene | ENSG00000181282 | OR5AK3P | chr11:56970850-56972146:+ | Tdark | 0 |
| olfactory receptor family 7 subfamily E member 87 pseudogene | ENSG00000184055 | OR7E87P | chr11:71593454-71594382:+ | 0 | |
| dopamine receptor D5 pseudogene 1 | ENSG00000184303 | DRD5P1 | chr2:91684447-91685884:- | 0 | |
| olfactory receptor family 10 subfamily D member 4 pseudogene | ENSG00000186268 | OR10D4P | chr11:124093582-124094532:- | Tdark | 0 |
| serpin family A member 13, pseudogene | ENSG00000187483 | SERPINA13P | chr14:94640725-94646994:+ | Tdark | 0.642857 |
| olfactory receptor family 11 subfamily H member 13 pseudogene | ENSG00000196143 | OR11H13P | chr14:19180291-19181269:+ | 0 | |
| serine protease 29, pseudogene | ENSG00000196364 | PRSS29P | chr16:1260952-1263845:- | Tdark | 0 |
| ADAM metallopeptidase domain 3A (pseudogene) | ENSG00000197475 | ADAM3A | chr8:39451045-39522852:- | 0 | |
| olfactory receptor family 14 subfamily L member 1 pseudogene | ENSG00000198452 | OR14L1P | chr1:247619643-247620570:+ | Tdark | 0 |
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