PDGs
The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .
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| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | TDL | PubTator Score |
| olfactory receptor family 2 subfamily A member 42 | ENSG00000212807 | OR2A42 | chr7:144231911-144232843:- | 0 | |
| olfactory receptor family 5 subfamily K member 1 | ENSG00000232382 | OR5K1 | chr3:98469480-98470576:+ | Tdark | 52.8167 |
| olfactory receptor family 4 subfamily C member 12 | ENSG00000221954 | OR4C12 | chr11:49981473-49982535:- | Tdark | 0.583333 |
| olfactory receptor family 52 subfamily N member 5 | ENSG00000181009 | OR52N5 | chr11:5777634-5778667:- | Tdark | 0 |
| olfactory receptor family 5 subfamily H member 15 | ENSG00000233412 | OR5H15 | chr3:98168700-98198138:+ | Tdark | 0 |
| olfactory receptor family 4 subfamily A member 47 | ENSG00000237388 | OR4A47 | chr11:48488717-48489780:+ | Tdark | 0 |
| olfactory receptor family 5 subfamily AC member 2 | ENSG00000196578 | OR5AC2 | chr3:98087173-98088102:+ | Tdark | 28.0845 |
| olfactory receptor family 6 subfamily V member 1 | ENSG00000225781 | OR6V1 | chr7:143052320-143053347:+ | Tdark | 0.642857 |
| olfactory receptor family 5 subfamily B member 3 | ENSG00000172769 | OR5B3 | chr11:58402464-58403409:- | Tdark | 0.333333 |
| olfactory receptor family 52 subfamily W member 1 | ENSG00000175485 | OR52W1 | chr11:6199146-6200259:+ | Tdark | 1 |
| MT-RNR2 like 5 | ENSG00000249860 | MTRNR2L5 | chr10:55599303-55600041:+ | Tbio | 0 |
| tudor domain containing 15 | ENSG00000218819 | TDRD15 | chr2:21123917-21143272:+ | Tdark | 0 |
| opsin 1, medium wave sensitive 2 | ENSG00000166160 | OPN1MW2 | chrX:154219756-154233286:+ | Tdark | 0 |
| olfactory receptor family 4 subfamily D member 11 | ENSG00000176200 | OR4D11 | chr11:59503576-59504511:+ | Tdark | 0 |
| olfactory receptor family 1 subfamily K member 1 | ENSG00000165204 | OR1K1 | chr9:122800123-122801073:+ | Tdark | 0 |
| olfactory receptor family 2 subfamily AE member 1 | ENSG00000244623 | OR2AE1 | chr7:99875987-99877057:- | Tdark | 0 |
| olfactory receptor family 8 subfamily H member 2 | ENSG00000181767 | OR8H2 | chr11:56105018-56106055:+ | Tdark | 0 |
| olfactory receptor family 8 subfamily H member 1 | ENSG00000181693 | OR8H1 | chr11:56290053-56291090:- | Tdark | 0 |
| olfactory receptor family 4 subfamily X member 1 | ENSG00000176567 | OR4X1 | chr11:48263861-48264778:+ | Tdark | 2.5 |
| olfactory receptor family 5 subfamily M member 9 | ENSG00000150269 | OR5M9 | chr11:56462469-56463401:- | Tdark | 0 |
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