PDGs
The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .
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| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | TDL | PubTator Score |
| otolin 1 | ENSG00000182447 | OTOL1 | chr3:161496808-161503942:+ | Tbio | 4.44444 |
| olfactory receptor family 51 subfamily L member 1 | ENSG00000176798 | OR51L1 | chr11:4998983-4999930:+ | Tdark | 1.14286 |
| phosphodiesterase 6H | ENSG00000139053 | PDE6H | chr12:14973022-14981865:+ | Tclin | 6.47897 |
| olfactory receptor family 6 subfamily M member 1 | ENSG00000196099 | OR6M1 | chr11:123805335-123806387:- | Tdark | 0 |
| olfactory receptor family 2 subfamily F member 2 | ENSG00000221910 | OR2F2 | chr7:143935166-143936279:+ | Tdark | 33.3667 |
| olfactory receptor family 6 subfamily X member 1 | ENSG00000221931 | OR6X1 | chr11:123753488-123754545:- | Tdark | 0.083333 |
| olfactory receptor family 4 subfamily M member 1 | ENSG00000176299 | OR4M1 | chr14:19780242-19781357:+ | Tdark | 24.8333 |
| olfactory receptor family 4 subfamily E member 2 | ENSG00000221977 | OR4E2 | chr14:21665083-21666024:+ | Tdark | 0 |
| olfactory receptor family 8 subfamily S member 1 | ENSG00000197376 | OR8S1 | chr12:48507354-48529897:+ | Tdark | 0.1 |
| olfactory receptor family 10 subfamily H member 4 | ENSG00000176231 | OR10H4 | chr19:15949008-15949958:+ | Tdark | 0 |
| olfactory receptor family 51 subfamily B member 5 | ENSG00000242180 | OR51B5 | chr11:5342586-5343524:- | Tdark | 1.25 |
| olfactory receptor family 5 subfamily M member 10 | ENSG00000254834 | OR5M10 | chr11:56576774-56577721:- | Tdark | 0 |
| sperm acrosome associated 5 | ENSG00000171489 | SPACA5 | chrX:48004336-48009729:+ | Tdark | 0 |
| olfactory receptor family 52 subfamily E member 4 | ENSG00000180974 | OR52E4 | chr11:5884271-5885300:+ | Tdark | 0 |
| olfactory receptor family 14 subfamily A member 2 | ENSG00000241128 | OR14A2 | chr1:247723099-247724043:- | Tdark | 0 |
| solute carrier family 25 member 52 | ENSG00000141437 | SLC25A52 | chr18:31759562-31760880:- | Tdark | 0.309524 |
| olfactory receptor family 8 subfamily I member 2 | ENSG00000172154 | OR8I2 | chr11:56093308-56094240:+ | Tdark | 0 |
| olfactory receptor family 6 subfamily C member 3 | ENSG00000205329 | OR6C3 | chr12:55331701-55332636:+ | Tdark | 7.47778 |
| olfactory receptor family 5 subfamily W member 2 | ENSG00000187612 | OR5W2 | chr11:55913650-55914582:- | Tdark | 0 |
| olfactory receptor family 51 subfamily I member 1 | ENSG00000167359 | OR51I1 | chr11:5440570-5441514:- | Tdark | 0 |
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