PDGs
The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .
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| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | TDL | PubTator Score |
| olfactory receptor family 4 subfamily L member 1 | ENSG00000176246 | OR4L1 | chr14:20060045-20060983:+ | Tdark | 2 |
| G protein-coupled receptor 21 | ENSG00000188394 | GPR21 | chr9:123034527-123035696:+ | Tdark | 2.47024 |
| olfactory receptor family 52 subfamily A member 1 | ENSG00000182070 | OR52A1 | chr11:5151009-5186382:- | Tdark | 0.583333 |
| olfactory receptor family 3 subfamily A member 3 | ENSG00000159961 | OR3A3 | chr17:3420568-3421533:+ | Tdark | 2 |
| lysozyme like 6 | ENSG00000275722 | LYZL6 | chr17:35934518-35943699:- | Tbio | 4.11667 |
| taste 2 receptor member 40 | ENSG00000221937 | TAS2R40 | chr7:143222037-143223079:+ | Tbio | 0.5 |
| olfactory receptor family 8 subfamily B member 8 | ENSG00000197125 | OR8B8 | chr11:124440126-124441158:- | Tdark | 0.361111 |
| olfactory receptor family 14 subfamily J member 1 | ENSG00000204695 | OR14J1 | chr6:29306690-29307655:+ | Tdark | 8 |
| proteasome 20S subunit alpha 8 | ENSG00000154611 | PSMA8 | chr18:26133852-26193355:+ | Tdark | 0.333333 |
| olfactory receptor family 52 subfamily N member 1 | ENSG00000181001 | OR52N1 | chr11:5787854-5788816:- | Tdark | 0 |
| olfactory receptor family 9 subfamily G member 1 | ENSG00000174914 | OR9G1 | chr11:56700388-56701305:+ | Tdark | 0 |
| olfactory receptor family 56 subfamily A member 4 | ENSG00000183389 | OR56A4 | chr11:6001986-6003194:- | Tdark | 1 |
| olfactory receptor family 6 subfamily B member 1 | ENSG00000221813 | OR6B1 | chr7:144003929-144004983:+ | Tdark | 23.7 |
| olfactory receptor family 51 subfamily G member 2 | ENSG00000176893 | OR51G2 | chr11:4914719-4915663:- | Tdark | 0 |
| olfactory receptor family 5 subfamily AU member 1 | ENSG00000169327 | OR5AU1 | chr14:21154865-21156063:- | Tdark | 0 |
| amylase alpha 1A | ENSG00000237763 | AMY1A | chr1:103655290-103664554:+ | Tchem | 4.11667 |
| G protein-coupled receptor 151 | ENSG00000173250 | GPR151 | chr5:146513103-146516190:- | Tbio | 1.36905 |
| olfactory receptor family 5 subfamily M member 1 | ENSG00000255012 | OR5M1 | chr11:56612555-56613502:- | Tdark | 0 |
| olfactory receptor family 51 subfamily I member 2 | ENSG00000187918 | OR51I2 | chr11:5453489-5454427:+ | Tdark | 0 |
| olfactory receptor family 4 subfamily D member 9 | ENSG00000172742 | OR4D9 | chr11:59514913-59515857:+ | Tdark | 0 |
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