PDGs
The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .
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| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | TDL | PubTator Score |
| ADAM metallopeptidase domain 20 | ENSG00000134007 | ADAM20 | chr14:70522358-70535015:- | Tdark | 2.83333 |
| short chain dehydrogenase/reductase family 42E, member 2 | ENSG00000183921 | SDR42E2 | chr16:22165583-22191754:+ | Tdark | 0 |
| olfactory receptor family 14 subfamily K member 1 | ENSG00000153230 | OR14K1 | chr1:247738615-247739559:+ | Tdark | 0 |
| olfactory receptor family 52 subfamily A member 5 | ENSG00000171944 | OR52A5 | chr11:5131692-5132642:- | Tdark | 1.58333 |
| amelogenin Y-linked | ENSG00000099721 | AMELY | chrY:6865918-6874027:- | Tbio | 34.2079 |
| MT-RNR2 like 10 | ENSG00000256045 | MTRNR2L10 | chrX:55181391-55182920:- | Tdark | 0 |
| olfactory receptor family 8 subfamily B member 2 | ENSG00000204293 | OR8B2 | chr11:124382395-124383362:- | Tdark | 0 |
| olfactory receptor family 4 subfamily D member 2 | ENSG00000255713 | OR4D2 | chr17:58169656-58170579:+ | Tdark | 0 |
| olfactory receptor family 6 subfamily P member 1 | ENSG00000186440 | OR6P1 | chr1:158562651-158563604:- | Tdark | 0 |
| solute carrier family 35 member F4 | ENSG00000151812 | SLC35F4 | chr14:57563922-57982194:- | Tdark | 0.111111 |
| serine peptidase inhibitor Kazal type 14 (putative) | ENSG00000196800 | SPINK14 | chr5:148169733-148175398:+ | Tdark | 0 |
| prostate and testis expressed 4 | ENSG00000237353 | PATE4 | chr11:125833316-125840069:+ | Tdark | 1 |
| olfactory receptor family 6 subfamily Y member 1 | ENSG00000197532 | OR6Y1 | chr1:158547128-158548105:- | Tdark | 0 |
| olfactory receptor family 4 subfamily A member 15 | ENSG00000181958 | OR4A15 | chr11:55367884-55368918:+ | Tdark | 0 |
| olfactory receptor family 52 subfamily D member 1 | ENSG00000181609 | OR52D1 | chr11:5488685-5489749:+ | Tdark | 0.5 |
| defensin beta 104A | ENSG00000176782 | DEFB104A | chr8:7836471-7841242:+ | 0 | |
| olfactory receptor family 51 subfamily D member 1 | ENSG00000197428 | OR51D1 | chr11:4639715-4640838:+ | Tdark | 1 |
| olfactory receptor family 5 subfamily H member 14 | ENSG00000236032 | OR5H14 | chr3:98149326-98150405:+ | Tdark | 0 |
| olfactory receptor family 52 subfamily I member 2 | ENSG00000226288 | OR52I2 | chr11:4586791-4587905:+ | Tdark | 0 |
| olfactory receptor family 11 subfamily H member 12 | ENSG00000257115 | OR11H12 | chr14:18601045-18602129:+ | Tdark | 0 |
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