PDGs
The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .
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| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | TDL | PubTator Score |
| olfactory receptor family 2 subfamily D member 3 | ENSG00000178358 | OR2D3 | chr11:6920974-6922043:+ | Tdark | 1 |
| olfactory receptor family 4 subfamily F member 17 | ENSG00000176695 | OR4F17 | chr19:107461-111696:+ | Tdark | 0.5 |
| olfactory receptor family 52 subfamily J member 3 | ENSG00000205495 | OR52J3 | chr11:5046526-5047461:+ | Tdark | 0.392857 |
| olfactory receptor family 4 subfamily K member 2 | ENSG00000165762 | OR4K2 | chr14:19876232-19877309:+ | Tdark | 0 |
| olfactory receptor family 52 subfamily M member 1 | ENSG00000197790 | OR52M1 | chr11:4545191-4546144:+ | Tdark | 0 |
| lipocalin 9 | ENSG00000148386 | LCN9 | chr9:135663322-135666422:+ | Tdark | 0 |
| olfactory receptor family 10 subfamily W member 1 | ENSG00000172772 | OR10W1 | chr11:58266792-58268260:- | Tdark | 0 |
| olfactory receptor family 10 subfamily A member 4 | ENSG00000170782 | OR10A4 | chr11:6876625-6877619:+ | Tbio | 1.86111 |
| ribonuclease A family member 8 | ENSG00000173431 | RNASE8 | chr14:21057822-21058455:+ | Tbio | 6.33333 |
| olfactory receptor family 10 subfamily G member 7 | ENSG00000182634 | OR10G7 | chr11:124038066-124039010:- | Tdark | 0 |
| lacritin | ENSG00000135413 | LACRT | chr12:54630811-54634895:- | Tbio | 30.1944 |
| serine protease 48 | ENSG00000189099 | PRSS48 | chr4:151277171-151291453:+ | Tdark | 0 |
| olfactory receptor family 4 subfamily K member 14 | ENSG00000169484 | OR4K14 | chr14:20014260-20015193:- | Tdark | 0 |
| olfactory receptor family 11 subfamily G member 2 | ENSG00000196832 | OR11G2 | chr14:20197336-20198446:+ | Tdark | 0 |
| G protein-coupled receptor 33 | ENSG00000214943 | GPR33 | chr14:31482964-31487945:- | Tdark | 1.16667 |
| G protein-coupled receptor 42 | ENSG00000126251 | GPR42 | chr19:35370929-35372962:+ | Tdark | 1.16667 |
| olfactory receptor family 52 subfamily B member 2 | ENSG00000255307 | OR52B2 | chr11:6169330-6170408:- | Tdark | 0 |
| taste 2 receptor member 8 | ENSG00000121314 | TAS2R8 | chr12:10806051-10807293:- | Tbio | 2.77692 |
| neuromedin U receptor 2 | ENSG00000132911 | NMUR2 | chr5:152391532-152433368:- | Tchem | 42.5579 |
| olfactory receptor family 4 subfamily N member 4 | ENSG00000183706 | OR4N4 | chr15:22094431-22095556:+ | Tdark | 0.7 |
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