PDGs
The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .
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| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | TDL | PubTator Score |
| olfactory receptor family 5 subfamily H member 6 | ENSG00000230301 | OR5H6 | chr3:98264285-98265262:+ | Tdark | 5.58333 |
| olfactory receptor family 9 subfamily Q member 1 | ENSG00000186509 | OR9Q1 | chr11:58023881-58181616:+ | Tdark | 0 |
| olfactory receptor family 10 subfamily H member 2 | ENSG00000171942 | OR10H2 | chr19:15728020-15729060:+ | Tdark | 0 |
| olfactory receptor family 2 subfamily G member 2 | ENSG00000177489 | OR2G2 | chr1:247588360-247589313:+ | Tdark | 27.3333 |
| olfactory receptor family 51 subfamily B member 6 | ENSG00000176239 | OR51B6 | chr11:5351508-5352446:+ | Tdark | 0.583333 |
| olfactory receptor family 7 subfamily G member 1 | ENSG00000161807 | OR7G1 | chr19:9114828-9115763:- | Tdark | 0 |
| olfactory receptor family 7 subfamily G member 3 | ENSG00000170920 | OR7G3 | chr19:9126012-9126950:- | Tdark | 0.833333 |
| potassium voltage-gated channel subfamily A member 6 | ENSG00000151079 | KCNA6 | chr12:4809176-4813412:+ | Tclin | 21.4446 |
| olfactory receptor family 51 subfamily A member 7 | ENSG00000176895 | OR51A7 | chr11:4907370-4908308:+ | Tdark | 0 |
| upper zone of growth plate and cartilage matrix associated | ENSG00000165623 | UCMA | chr10:13221767-13234334:- | Tbio | 9.11667 |
| olfactory receptor family 5 subfamily H member 2 | ENSG00000197938 | OR5H2 | chr3:98282888-98283832:+ | Tdark | 6.5 |
| olfactory receptor family 5 subfamily A member 1 | ENSG00000172320 | OR5A1 | chr11:59443144-59444194:+ | Tdark | 1 |
| MT-RNR2 like 4 | ENSG00000232196 | MTRNR2L4 | chr16:3370979-3372740:- | Tdark | 0.125 |
| olfactory receptor family 2 subfamily L member 8 | ENSG00000196936 | OR2L8 | chr1:247948858-247949796:+ | Tdark | 0.142857 |
| defensin alpha 1 | ENSG00000206047 | DEFA1 | chr8:6977649-6980080:- | 0 | |
| testis specific serine kinase 2 | ENSG00000206203 | TSSK2 | chr22:19130808-19132623:+ | Tbio | 8.66071 |
| sperm associated antigen 11B | ENSG00000164871 | SPAG11B | chr8:7442684-7463674:- | Tbio | 15.2125 |
| bone morphogenetic protein 10 | ENSG00000163217 | BMP10 | chr2:68865481-68871517:- | Tbio | 14.354 |
| testis specific serine kinase 1B | ENSG00000212122 | TSSK1B | chr5:113432554-113435031:- | Tchem | 5.25952 |
| insulin like 5 | ENSG00000172410 | INSL5 | chr1:66797741-66801256:- | Tbio | 14.6896 |
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