PDGs
The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .
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| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | TDL | PubTator Score |
| olfactory receptor family 56 subfamily A member 1 | ENSG00000180934 | OR56A1 | chr11:6026671-6027741:- | Tdark | 0 |
| WAP four-disulfide core domain 8 | ENSG00000158901 | WFDC8 | chr20:45551153-45579326:- | Tdark | 2.19444 |
| defensin beta 110 | ENSG00000203970 | DEFB110 | chr6:50009138-50021981:- | Tdark | 1 |
| G protein-coupled receptor 149 | ENSG00000174948 | GPR149 | chr3:154337672-154429715:- | Tdark | 1.5 |
| olfactory receptor family 10 subfamily J member 3 | ENSG00000196266 | OR10J3 | chr1:159313670-159314659:- | Tdark | 0.058824 |
| olfactory receptor family 6 subfamily K member 2 | ENSG00000196171 | OR6K2 | chr1:158699678-158700652:- | Tdark | 24.1944 |
| olfactory receptor family 6 subfamily C member 2 | ENSG00000179695 | OR6C2 | chr12:55452214-55453152:+ | Tdark | 19.8185 |
| glutathione peroxidase 6 | ENSG00000198704 | GPX6 | chr6:28503296-28528215:- | Tdark | 4.14005 |
| defensin beta 115 | ENSG00000215547 | DEFB115 | chr20:31257664-31259632:+ | Tdark | 0 |
| olfactory receptor family 1 subfamily D member 5 | ENSG00000262628 | OR1D5 | chr17:3062669-3063607:- | Tdark | 3 |
| olfactory receptor family 14 subfamily C member 36 | ENSG00000177174 | OR14C36 | chr1:248348775-248349713:+ | Tdark | 0.166667 |
| olfactory receptor family 2 subfamily V member 2 | ENSG00000182613 | OR2V2 | chr5:181154943-181155890:+ | Tdark | 0 |
| olfactory receptor family 6 subfamily T member 1 | ENSG00000181499 | OR6T1 | chr11:123942785-123943873:- | Tdark | 0 |
| opsin 1, long wave sensitive | ENSG00000102076 | OPN1LW | chrX:154144224-154159032:+ | Tbio | 80.4167 |
| 5-hydroxytryptamine receptor 3D | ENSG00000186090 | HTR3D | chr3:184031544-184039369:+ | Tchem | 0.95 |
| pepsinogen A3 | ENSG00000229859 | PGA3 | chr11:61203307-61213098:+ | Tbio | 15.0833 |
| olfactory receptor family 10 subfamily Z member 1 | ENSG00000198967 | OR10Z1 | chr1:158606439-158607380:+ | Tdark | 0 |
| taste 2 receptor member 3 | ENSG00000127362 | TAS2R3 | chr7:141764097-141765197:+ | Tbio | 2.25 |
| defensin beta 127 | ENSG00000088782 | DEFB127 | chr20:157470-159163:+ | Tbio | 1.5 |
| olfactory receptor family 51 subfamily J member 1 | ENSG00000184321 | OR51J1 | chr11:5402597-5403547:+ | Tdark | 0 |
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