PDGs
The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .
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| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | TDL | PubTator Score |
| serine protease 54 | ENSG00000103023 | PRSS54 | chr16:58279997-58295047:- | Tdark | 0 |
| ataxin 3 like | ENSG00000123594 | ATXN3L | chrX:13318236-13319952:- | Tbio | 0.333333 |
| olfactory receptor family 13 subfamily C member 5 | ENSG00000277556 | OR13C5 | chr9:104598457-104599413:- | Tdark | 0 |
| potassium two pore domain channel subfamily K member 4 | ENSG00000182450 | KCNK4 | chr11:64291302-64300031:+ | Tbio | 26.3757 |
| taste 2 receptor member 16 | ENSG00000128519 | TAS2R16 | chr7:122994704-122995700:- | Tbio | 25.35 |
| olfactory receptor family 51 subfamily Q member 1 | ENSG00000167360 | OR51Q1 | chr11:5422111-5423206:+ | Tdark | 0 |
| olfactory receptor family 52 subfamily E member 6 | ENSG00000205409 | OR52E6 | chr11:5840928-5841952:- | Tdark | 0 |
| solute carrier family 2 member 7 | ENSG00000197241 | SLC2A7 | chr1:9003300-9026345:- | Tdark | 6.79167 |
| olfactory receptor family 6 subfamily A member 2 | ENSG00000184933 | OR6A2 | chr11:6794627-6795783:- | Tdark | 8.67222 |
| transmembrane serine protease 7 | ENSG00000176040 | TMPRSS7 | chr3:112034843-112081269:+ | Tdark | 0.866667 |
| olfactory receptor family 1 subfamily N member 1 | ENSG00000171505 | OR1N1 | chr9:122526358-122527296:- | Tdark | 12.5 |
| olfactory receptor family 4 subfamily D member 10 | ENSG00000254466 | OR4D10 | chr11:59477373-59478396:+ | Tdark | 0 |
| olfactory receptor family 5 subfamily B member 12 | ENSG00000172362 | OR5B12 | chr11:58439120-58440173:- | Tdark | 0 |
| olfactory receptor family 51 subfamily M member 1 | ENSG00000184698 | OR51M1 | chr11:5389399-5390379:+ | Tdark | 0 |
| sperm adhesion molecule 1 | ENSG00000106304 | SPAM1 | chr7:123925237-123971414:+ | Tbio | 71.5968 |
| olfactory receptor family 2 subfamily T member 6 | ENSG00000198104 | OR2T6 | chr1:248387609-248388535:+ | Tdark | 0 |
| olfactory receptor family 1 subfamily Q member 1 | ENSG00000165202 | OR1Q1 | chr9:122614738-122615682:+ | Tdark | 3.25 |
| glutathione peroxidase 5 | ENSG00000224586 | GPX5 | chr6:28525925-28534952:+ | Tbio | 16.6012 |
| ATP/GTP binding protein like 1 | ENSG00000166748 | AGBL1 | chr15:86141996-87029052:+ | Tbio | 52.7845 |
| olfactory receptor family 2 subfamily L member 2 | ENSG00000203663 | OR2L2 | chr1:248038268-248039206:+ | Tdark | 6 |
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